For research use only. Not for therapeutic Use.
Triapine (Cat No.:I001685) is a synthetic small molecule with antineoplastic properties. It belongs to the class of thiosemicarbazone compounds. Triapine acts as an inhibitor of ribonucleotide reductase (RNR), an enzyme essential for DNA synthesis. By inhibiting RNR, Triapine disrupts the production of deoxynucleotides, leading to DNA damage and inhibition of cell proliferation. It has shown potential as a chemotherapeutic agent in the treatment of various cancers, including ovarian, cervical, and pancreatic cancer. Triapine’s unique mechanism of action and broad-spectrum antitumor activity make it an interesting candidate for further research and clinical investigation.
| Catalog Number | I001685 |
| CAS Number | 143621-35-6 |
| Synonyms | 3AP; 3AP; 3Apct; OCX 191; OCX191; OCX191; AIDS179996; AIDS179996; NSC663249. PAN-811; PAN811; PAN 811; Triapine;2-[(3-amino-2-pyridinyl)methylene]-hydrazinecarbothioamide |
| Molecular Formula | C₇H₉N₅S |
| Purity | ≥95% |
| Target | DNA/RNA Synthesis |
| Solubility | DMSO: ≥ 47 mg/mL |
| Storage | Store at -20°C |
| Overview of Clinical Research | Originator: Yale University<br /> |
| IUPAC Name | [(E)-(3-aminopyridin-2-yl)methylideneamino]thiourea |
| InChI | InChI=1S/C7H9N5S/c8-5-2-1-3-10-6(5)4-11-12-7(9)13/h1-4H,8H2,(H3,9,12,13)/b11-4+ |
| InChIKey | XMYKNCNAZKMVQN-NYYWCZLTSA-N |
| SMILES | C1=CC(=C(N=C1)/C=N/NC(=S)N)N |
| Reference | 1: Chitambar CR, Antholine WE. Iron-targeting antitumor activity of gallium |
