For research use only. Not for therapeutic Use.
Triaziquone It is an alkylating agent. It can react with DNA to form intrastrand crosslinks.
| Catalog Number | I009876 |
| CAS Number | 68-76-8 |
| Synonyms | A 163; A 163; A 163; Triaziquone; Trenimon; Trenimone; Triazichon;2,3,5-tri(aziridin-1-yl)cyclohexa-2,5-diene-1,4-dione |
| Molecular Formula | C12H13N3O2 |
| Purity | ≥95% |
| Target | DNA/RNA Synthesis |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 2,3,5-tris(aziridin-1-yl)cyclohexa-2,5-diene-1,4-dione |
| InChI | InChI=1S/C12H13N3O2/c16-9-7-8(13-1-2-13)12(17)11(15-5-6-15)10(9)14-3-4-14/h7H,1-6H2 |
| InChIKey | PXSOHRWMIRDKMP-UHFFFAOYSA-N |
| SMILES | C1CN1C2=CC(=O)C(=C(C2=O)N3CC3)N4CC4 |
| Reference | </br>1:A study on inhibition mechanism of breast cancer cells by bis-type triaziquone. Lin YL, Su YT, Chen BH.Eur J Pharmacol. 2010 Jul 10;637(1-3):1-10. doi: 10.1016/j.ejphar.2010.03.034. Epub 2010 Apr 2. PMID: 20371239 </br>2:Synthesis and antitumor evaluation of novel bis-triaziquone derivatives. Huang CH, Kuo HS, Liu JW, Lin YL.Molecules. 2009 Jun 29;14(7):2306-16. doi: 10.3390/molecules14072306. PMID: 19633605 Free Article</br>3:A sequential analysis of meiosis in the male mouse using a restricted spermatocyte population obtained by a hydroxyurea/triaziquone treatment. Oud JL, de Jong JH, de Rooij DG.Chromosoma. 1979 Feb 21;71(2):237-48. PMID: 371933 </br>4:A sequential screening of the cytogenetic damage induced by triaziquone. Oud JL, Peters PW.Mutat Res. 1978 Oct;54(2):175-84. PMID: 362189 </br>5:Comparisons of the chemical and biologic properties of triaziquone and triaziquone-protein conjugates. Linford JH, Froese G.J Natl Cancer Inst. 1978 Feb;60(2):307-16. PMID: 74416 </br>6:Effects of caffeine on sister chromatid exchange (SCE) after exposure to UV light or triaziquone studied with a fluorescence plus giemsa (FPG) technique. Vogel W, Bauknecht T.Hum Genet. 1978 Jan 19;40(2):193-8. PMID: 624547 </br>7:Chromosome aberrations in metaphase II oocytes of Chinese hamster (Cricetulus griseus). I. The sensitivity of the pre-ovulatory phase to triaziquone. Hansmann I, Neher J, Röhrborn G.Mutat Res. 1974 Dec;25(3):347-59. No abstract available. PMID: 4437573 </br>8:Induced dominant lethals in female mice: effects of triaziquone and phenylbutazone. Machemer L, Hess R.Experientia. 1973 Feb 15;29(2):190-2. No abstract available. PMID: 4692764 </br>9:[Comparative studies using the urine metabolites of cyclophosphamide, bis-(2-chloroethyl)amine and triaziquone on Lactobacillus fermenti ATCC 9338]. Norpoth K, Modlich W, Schumacher H, Rauen HM.Arzneimittelforschung. 1972 Oct;22(10):1784-8. German. No abstract available. PMID: 4677072 </br>10:[Study on the reproducibility of the dominant lethal test in the mouse using cyclophosphamide and triaziquone]. Machemer L, Stenger EG.Arzneimittelforschung. 1971 Jul;21(7):1037-9. German. No abstract available. PMID: 5109493 |
