Tributyrin

• CAT Number: R027549
• CAS Number: 60-01-5
• Molecular Formula: C15H26O6
• Molecular Weight: 302.367
• Purity: ≥95%
• Synonyms: Glyceryl Tributyrate; Butyrin; Butyryl triglyceride; Glycerin tributyrate; Glycerol tributanoate; Glycerol tributyrate; Glyceroltributyrin; Glyceryl tributanoate; Glyceryl tributyrate; NSC 661583; Tri-n-butyrin; Tributanoin; Tributin; Tributyroin; Tr
• Target: Apoptosis
• Storage: -20°C
• IUPAC Name: 2,3-di(butanoyloxy)propyl butanoate
• InChI: InChI=1S/C15H26O6/c1-4-7-13(16)19-10-12(21-15(18)9-6-3)11-20-14(17)8-5-2/h12H,4-11H2,1-3H3
• InChIKey: UYXTWWCETRIEDR-UHFFFAOYSA-N
• SMILES: CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC

Tributyrin (CAS 60-01-5), also known as NSC661583, is a histone deacetylase (HDAC) inhibitor potentially for the treatment of solid tumors. It is a triglyceride prodrug of butyric acid with potential antineoplastic activity.

Overview of Clinical Research

Tributyrin is a cell differentiation stimulant. The Phase-I clinical trials for Solid tumours in USA (PO) started in 1998.

Reference

1:In Vitro Digestion and Fermentation of Microencapsulated Tributyrin for the Delivery of Butyrate. Donovan JD, Bauer L, Fahey GC Jr, Lee Y.J Food Sci. 2017 May 9. doi: 10.1111/1750-3841.13725. [Epub ahead of print] PMID: 28485486
2:Enhanced base-catalyzed activity and structural stability of nitrogen-doped carbon modified MgO-MgFe2O4 magnetic composites as catalysts for transesterification of tributyrin. Zhang Y, Zhang M, Yang L, Fan G, Li F.Dalton Trans. 2017 May 16;46(19):6324-6332. doi: 10.1039/c7dt00689f. PMID: 28453008
3:Dietary supplementation with tributyrin prevented weaned pigs from growth retardation and lethal infection via modulation of inflammatory cytokines production, ileal expression, and intestinal acetate fermentation. Gu Y, Song Y, Yin H, Lin S, Zhang X, Che L, Lin Y, Xu S, Feng B, Wu D, Fang Z.J Anim Sci. 2017 Jan;95(1):226-238. doi: 10.2527/jas.2016.0911. PMID: 28177354
4:Prophylactic tributyrin treatment mitigates chronic-binge alcohol-induced intestinal barrier and liver injury. Cresci GA, Glueck B, McMullen MR, Xin W, Allende D, Nagy LE.J Gastroenterol Hepatol. 2017 Jan 14. doi: 10.1111/jgh.13731. [Epub ahead of print] PMID: 28087985
5:R-Index Measure of Microencapsulated Tributyrin in Gamma-Cyclodextrin Influenced by Drying Method. Donovan JD, Lee SY, Lee Y.J Food Sci. 2016 Sep;81(9):S2252-7. doi: 10.1111/1750-3841.13415. Epub 2016 Aug 16. PMID: 27527112
6:Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein. Ortega JF, de Conti A, Tryndyak V, Furtado KS, Heidor R, Horst MA, Fernandes LH, Tavares PE, Pogribna M, Shpyleva S, Beland FA, Pogribny IP, Moreno FS.Oncotarget. 2016 Apr 26;7(17):24339-47. doi: 10.18632/oncotarget.8248. PMID: 27013579 Free PMC Article
7:Volatile Retention and Morphological Properties of Microencapsulated Tributyrin Varied by Wall Material and Drying Method. Donovan JD, Cadwallader KR, Lee Y.J Food Sci. 2016 Mar;81(3):E643-50. doi: 10.1111/1750-3841.13243. Epub 2016 Feb 15. PMID: 26878682
8:Effect of Tributyrin on Electrical Activity in the Small Intestine during Early Postoperative Period. Tropskaya NS, Kislyakova EA, Popova TS.Bull Exp Biol Med. 2015 Dec;160(2):219-22. doi: 10.1007/s10517-015-3133-0. Epub 2015 Dec 8. PMID: 26645288
9:Effects of Tributyrin on Intestinal Energy Status, Antioxidative Capacity and Immune Response to Lipopolysaccharide Challenge in Broilers. Li J, Hou Y, Yi D, Zhang J, Wang L, Qiu H, Ding B, Gong J.Asian-Australas J Anim Sci. 2015 Dec;28(12):1784-93. doi: 10.5713/ajas.15.0286. PMID: 26580447 Free PMC Article
10:Dietary Tributyrin Supplementation Attenuates Insulin Resistance and Abnormal Lipid Metabolism in Suckling Piglets with Intrauterine Growth Retardation. He J, Dong L, Xu W, Bai K, Lu C, Wu Y, Huang Q, Zhang L, Wang T.PLoS One. 2015 Aug 28;10(8):e0136848. doi: 10.1371/journal.pone.0136848. eCollection 2015. PMID: 26317832 Free PMC Article