For research use only. Not for therapeutic Use.
Trichostatin A (Cat.No:I004204) is a potent and selective inhibitor of histone deacetylases (HDACs). It modulates chromatin structure by increasing histone acetylation, leading to altered gene expression. Trichostatin A is a valuable tool in epigenetic research, revealing insights into gene regulation and potential therapeutic applications in cancer and other diseases.
| Catalog Number | I004204 |
| CAS Number | 58880-19-6 |
| Synonyms | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide |
| Molecular Formula | C₁₇H₂₂N₂O₃ |
| Purity | ≥95% |
| Target | Cell Cycle/DNA Damage |
| Solubility | DMSO: ≥ 30 mg/mL |
| Storage | 3 years -20℃ powder |
| IC50 | ~1.8 nM |
| IUPAC Name | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide |
| InChI | InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1 |
| InChIKey | RTKIYFITIVXBLE-QEQCGCAPSA-N |
| SMILES | CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C |
| Reference | </br>1:Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer. Kudo K, Ozaki T, Shin-Ya K, Nishiyama M, Kuzuyama T.J Am Chem Soc. 2017 May 12. doi: 10.1021/jacs.7b02071. [Epub ahead of print] PMID: 28497964 </br>2:Treatment of Donor Cells and Reconstructed Embryos with a Combination of Trichostatin-A and 5-aza-2/’-Deoxycytidine Improves the Developmental Competence and Quality of Buffalo Embryos Produced by Handmade Cloning and Alters Their Epigenetic Status and Gene Expression. Saini M, Selokar NL, Agrawal H, Singla SK, Chauhan MS, Manik RS, Palta P.Cell Reprogram. 2017 May 2. doi: 10.1089/cell.2016.0061. [Epub ahead of print] PMID: 28463020 </br>3:Bioinformatic identification of candidate genes induced by trichostatin A in BGC-823 gastric cancer cells. Li Y, Zhang L, Yang C, Li R, Shang L, Zou X.Oncol Lett. 2017 Feb;13(2):777-783. doi: 10.3892/ol.2016.5485. Epub 2016 Dec 12. PMID: 28356958 Free PMC Article</br>4:Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway. Li LF, Lee CS, Lin CW, Chen NH, Chuang LP, Hung CY, Liu YY.PLoS One. 2017 Feb 24;12(2):e0172571. doi: 10.1371/journal.pone.0172571. eCollection 2017. PMID: 28234968 Free PMC Article</br>5:Effects of Trichostatin A and PXD101 on the In Vitro Development of Mouse Somatic Cell Nuclear Transfer Embryos. Qiu X, You H, Xiao X, Li N, Li Y.Cell Reprogram. 2017 Feb;19(1):1-9. doi: 10.1089/cell.2016.0030. PMID: 28112984 </br>6:PI3K/mTOR dual inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A synergistically exert anti-tumor activity in breast cancer. Chen L, Jin T, Zhu K, Piao Y, Quan T, Quan C, Lin Z.Oncotarget. 2017 Feb 14;8(7):11937-11949. doi: 10.18632/oncotarget.14442. PMID: 28060760 Free PMC Article</br>7:HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. Mazzio EA, Soliman KF.Cancer Genomics Proteomics. 2017 Jan 2;14(1):17-33. PMID: 28031235 Free PMC Article</br>8:Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miR‑375. Jia L, Zhang S, Huang Y, Zheng Y, Gan Y.Oncol Rep. 2017 Jan;37(1):305-312. doi: 10.3892/or.2016.5261. Epub 2016 Nov 18. PMID: 27878285 </br>9:Histone Deacetylase Inhibitor Trichostatin a Promotes the Apoptosis of Osteosarcoma Cells through p53 Signaling Pathway Activation. Deng Z, Liu X, Jin J, Xu H, Gao Q, Wang Y, Zhao J.Int J Biol Sci. 2016 Oct 18;12(11):1298-1308. eCollection 2016. PMID: 27877082 Free PMC Article</br>10:The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. Hrgovic I, Doll M, Kleemann J, Wang XF, Zoeller N, Pinter A, Kippenberger S, Kaufmann R, Meissner M.BMC Cancer. 2016 Sep 30;16(1):763. PMID: 27716272 Free PMC Article |
