For research use only. Not for therapeutic Use.
Triciribine phosphate (Cat.No:I009878) is a protein kinase B (PKB/Akt) inhibitor potentially for the treatment of ovarian cancer, and breast cancer.
| Catalog Number | I009878 |
| CAS Number | 61966-08-3 |
| Synonyms | VQD-002; TCN-P; PTX-200; PTX-002; NSC-280594; TCN P; VQD002; TCNP; PTX200; PTX002; NSC280594; VQD 002; TCN P; PTX 200; PTX 002; NSC 280594;;((2R,3S,4R,5R)-5-(3-amino-5-methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl |
| Molecular Formula | C13H17N6O7P |
| Purity | ≥95% |
| Target | ATP Synthase |
| Solubility | Soluble in DMSO |
| Storage | -20°C |
| InChI | InChI=1S/C13H17N6O7P/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(21)8(20)6(26-13)3-25-27(22,23)24/h2,4,6,8-9,13,20-21H,3H2,1H3,(H2,14,17)(H2,22,23,24)/t6-,8-,9-,13-/m1/s1 |
| InChIKey | URLYINUFLXOMHP-HTVVRFAVSA-N |
| SMILES | CN1C2=NC=NC3=C2C(=CN3C4C(C(C(O4)COP(=O)(O)O)O)O)C(=N1)N |
| Reference | </br>1:Triciribine Phosphate Monohydrate, an AKT Inhibitor, Enhances Gemcitabine Activity in Pancreatic Cancer Cells. Kim R, Yamauchi T, Husain K, Sebti S, Malafa M.Anticancer Res. 2015 Sep;35(9):4599-604. PMID: 26254348 </br>2:Phase I clinical, pharmacokinetic, and pharmacodynamic study of the Akt-inhibitor triciribine phosphate monohydrate in patients with advanced hematologic malignancies. Sampath D, Malik A, Plunkett W, Nowak B, Williams B, Burton M, Verstovsek S, Faderl S, Garcia-Manero G, List AF, Sebti S, Kantarjian HM, Ravandi F, Lancet JE.Leuk Res. 2013 Nov;37(11):1461-7. doi: 10.1016/j.leukres.2013.07.034. Epub 2013 Aug 6. PMID: 23993427 Free PMC Article</br>3:Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT. Garrett CR, Coppola D, Wenham RM, Cubitt CL, Neuger AM, Frost TJ, Lush RM, Sullivan DM, Cheng JQ, Sebti SM.Invest New Drugs. 2011 Dec;29(6):1381-9. doi: 10.1007/s10637-010-9479-2. Epub 2010 Jul 20. PMID: 20644979 Free PMC Article</br>4:Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN-P). Moore EC, Hurlbert RB, Boss GR, Massia SP.Biochem Pharmacol. 1989 Nov 15;38(22):4045-51. PMID: 2480792 </br>5:Mechanism of activation of triciribine phosphate (TCN-P) as a prodrug form of TCN. Wotring LL, Crabtree GW, Edwards NL, Parks RE Jr, Townsend LB.Cancer Treat Rep. 1986 Apr;70(4):491-7. PMID: 3698043 |
