Triclabendazole Sulfoxide

• CAT Number: R042343
• CAS Number: 100648-13-3
• Molecular Formula: C14H9Cl3N2O2S
• Molecular Weight: 375.65
• Purity: ≥95%
• Synonyms: 6-Chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfinyl)-1H-benzimidazole
• Storage: -20°C
• Related CAS: 109536-20-1;
• IUPAC Name: 6-chloro-5-(2,3-dichlorophenoxy)-2-methylsulfinyl-1H-benzimidazole
• InChI: InChI=1S/C14H9Cl3N2O2S/c1-22(20)14-18-9-5-8(16)12(6-10(9)19-14)21-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)
• InChIKey: GABQPFWIQFRJSE-UHFFFAOYSA-N
• SMILES: CS(=O)C1=NC2=CC(=C(C=C2N1)Cl)OC3=C(C(=CC=C3)Cl)Cl

Triclabendazole Sulfoxide（Cat No.:R042343）is the active metabolite of triclabendazole, a benzimidazole derivative highly effective against liver flukes (Fasciola hepatica and Fasciola gigantica). It disrupts the parasite’s microtubule function and energy metabolism, leading to its paralysis and death. Triclabendazole Sulfoxide exhibits excellent efficacy against both immature and adult fluke stages, making it a preferred treatment for fascioliasis in livestock and humans. Its broad-spectrum activity and safety profile support its use in veterinary and clinical medicine, contributing significantly to parasitic disease management in endemic regions.

Reference

1.Dupuy, Jacques, et al. "Interaction of anthelmintic drugs with P-glycoprotein in recombinant LLC-PK1-mdr1a cells." Chemico-biological interactions 186.3 (2010): 280-286.
2.Mestorino, N., et al. "Pharmacokinetic disposition of triclabendazole in cattle and sheep; discrimination of the order and the rate of the absorption process of its active metabolite triclabendazole sulfoxide." Veterinary research communications 32.1 (2008): 21-33.
3.Barrera, Borja, et al. "The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP." Antimicrobial agents and chemotherapy 56.7 (2012): 3535-3543.
4.Keiser, Jennifer, et al. "Triclabendazole and its two main metabolites lack activity against Schistosoma mansoni in the mouse model." The American journal of tropical medicine and hygiene 75.2 (2006): 287-291.
5.Mestorino, N., et al. "Pharmacokinetic disposition of triclabendazole in cattle and sheep; discrimination of the order and the rate of the absorption process of its active metabolite triclabendazole sulfoxide." Veterinary research communications 32.1 (2008): 21-33.
6.Halferty, L., et al. "Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica." Veterinary parasitology 159.2 (2009): 126-138.