Trifluoperazine dihydrochloride

• CAT Number: I003560
• CAS Number: 440-17-5
• Molecular Formula: C21H24F3N3S • 2HCl
• Molecular Weight: 480.40
• Purity: ≥95%
• Synonyms: 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;dihydrochloride
• Target: Autophagy
• Solubility: DMSO 88 mg/mL; Water 88 mg/mL
• Storage: 3 years -20C powder
• InChI: InChI=1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H
• InChIKey: BXDAOUXDMHXPDI-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl

Trifluoperazine dihydrochloride（Cat No.:I003560）is a first-generation antipsychotic medication belonging to the phenothiazine class. It works by blocking dopamine receptors in the brain, helping to manage symptoms of schizophrenia, anxiety, and other psychotic disorders. Trifluoperazine is also used in the treatment of severe nausea and vomiting, as well as in some non-psychotic disorders. It has both antipsychotic and antiemetic properties. While effective, it can cause side effects such as sedation, weight gain, and extrapyramidal symptoms like tremors and rigidity. Long-term use requires monitoring for potential neurological and metabolic side effects.

Reference

[1]. Huerta-Bahena, J., R. Villalobos-Molina, and J.A. Garcia-Sainz, Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects. Mol Pharmacol, 1983. 23(1): p. 67-70.

[2]. Marques, L.O., M.S. Lima, and B.G. Soares, Trifluoperazine for schizophrenia. Cochrane Database Syst Rev, 2004(1): p. CD003545.