For research use only. Not for therapeutic Use.
Trifluoromethyl-tubercidin (TFMT) is a 2′-O-ribose methyltransferase 1 (MTr1) inhibitor through interaction at its S-adenosyl-l-methionine binding pocket to restrict influenza virus replication[1].
| Catalog Number | I040685 |
| CAS Number | 1854086-05-7 |
| Synonyms | (2R,3R,4S,5R)-2-[4-amino-5-(trifluoromethyl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-(hydroxymethyl)oxolane-3,4-diol |
| Molecular Formula | C12H13F3N4O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C12H13F3N4O4/c13-12(14,15)4-1-19(10-6(4)9(16)17-3-18-10)11-8(22)7(21)5(2-20)23-11/h1,3,5,7-8,11,20-22H,2H2,(H2,16,17,18)/t5-,7-,8-,11-/m1/s1 |
| InChIKey | RSOXZOFDCJMRMK-IOSLPCCCSA-N |
| SMILES | C1=C(C2=C(N=CN=C2N1C3C(C(C(O3)CO)O)O)N)C(F)(F)F |
| Reference | [1]. Yuta Tsukamoto, et al. Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication. Science. 2023 Feb 10;379(6632):586-591. |
