Triheptanoin

For research use only. Not for therapeutic Use.

  • CAT Number: I011400
  • CAS Number: 620-67-7
  • Molecular Formula: C24H44O6
  • Molecular Weight: 428.61
  • Purity: 98%
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Triheptanoin (Cat No.:I011400) is a synthetic triglyceride compound consisting of three heptanoic acid (C7) molecules esterified to a glycerol backbone. It is a medium-chain triglyceride (MCT) and is metabolized differently than long-chain triglycerides (LCTs). Triheptanoin is primarily used as a therapeutic agent for the management of certain metabolic disorders, including fatty acid oxidation disorders (FAODs) and glucose transporter type 1 deficiency syndrome (GLUT1-DS). Due to its unique metabolism, triheptanoin provides an alternative energy source that can bypass the impaired metabolic pathways in these disorders. It is metabolized to generate ketone bodies, which can serve as an energy source for the brain and other tissues.


Catalog Number I011400
CAS Number 620-67-7
Synonyms

Dermofeel TC 7; Glycerol triheptanoate; Glyceryl triheptanoate; Lanol 37T?Trienanthoin; Triheptanoic glyceride; Triheptanoin; Trioenanthoin

Molecular Formula C24H44O6
Purity 98%
Target ALB
Target Protein

P02768

Appearance Solid
Storage Dry, dark and at 2 - 8 °C for six months or -20°C for two years.
IUPAC Name 2,3-di(heptanoyloxy)propyl heptanoate
InChI InChI=1S/C24H44O6/c1-4-7-10-13-16-22(25)28-19-21(30-24(27)18-15-12-9-6-3)20-29-23(26)17-14-11-8-5-2/h21H,4-20H2,1-3H3
InChIKey PJHKBYALYHRYSK-UHFFFAOYSA-N
SMILES CCCCCCC(=O)OCC(COC(=O)CCCCCC)OC(=O)CCCCCC
Reference

1: Kim TH, Borges K, Petrou S, Reid CA. Triheptanoin reduces seizure
susceptibility in a syndrome-specific mouse model of generalized epilepsy.
Epilepsy Res. 2013 Jan;103(1):101-5. doi: 10.1016/j.eplepsyres.2012.09.016. Epub
2012 Nov 26. PubMed PMID: 23196212.
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2: Thomas NK, Willis S, Sweetman L, Borges K. Triheptanoin in acute mouse seizure
models. Epilepsy Res. 2012 May;99(3):312-7. doi:
10.1016/j.eplepsyres.2011.12.013. Epub 2012 Jan 20. PubMed PMID: 22260920.

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3: Bueno NB, Silva MA, Melo IS, Ataíde Tda R, Oliveira SL, Sant/’Ana AE. [Hepatic
fatty acid profile of rats with AIN-93 diet-induced steatosis attenuated by the
partial substitution of soybean oil by diheptanoin and triheptanoin]. Arq Bras
Endocrinol Metabol. 2010 Aug;54(6):584-7. Portuguese. PubMed PMID: 20857067.

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4: Kinman RP, Kasumov T, Jobbins KA, Thomas KR, Adams JE, Brunengraber LN, Kutz
G, Brewer WU, Roe CR, Brunengraber H. Parenteral and enteral metabolism of
anaplerotic triheptanoin in normal rats. Am J Physiol Endocrinol Metab. 2006
Oct;291(4):E860-6. Epub 2006 May 16. PubMed PMID: 16705058.

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