For research use only. Not for therapeutic Use.
Trimeprazine (Cat.No:I009470), commonly provided as a tartrate salt, is a phenothiazine derivative that is used as an antipruritic (it prevents itching from causes such as eczema or poison ivy, by acting as an antihistamine). It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness. Although it is structurally related to drugs such as chlorpromazine, it is not used as an antipsychotic.
| Catalog Number | I009470 |
| CAS Number | 84-96-8 |
| Synonyms | Trimeprazine, Alimemazine, Methylpromazine, Alimezine, Repetin, Teralen;N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine |
| Molecular Formula | C18H22N2S |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine |
| InChI | InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3 |
| InChIKey | ZZHLYYDVIOPZBE-UHFFFAOYSA-N |
| SMILES | CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)CN(C)C |
| Reference | </br>1:Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. Kuznetsova A, Yu Y, Hollister-Lock J, Opare-Addo L, Rozzo A, Sadagurski M, Norquay L, Reed JE, El Khattabi I, Bonner-Weir S, Weir GC, Sharma A, White MF.JCI Insight. 2016;1(3). pii: e80749. Epub 2016 Mar 17. PMID: 27152363 Free PMC Article</br>2:Case report of atopic dermatitis with refractory pruritus markedly improved with the novel use of clonidine and trimeprazine. Genois A, Haig M, Des Roches A, Sirard A, Le May S, McCuaig CC.Pediatr Dermatol. 2014 Jan-Feb;31(1):76-9. doi: 10.1111/j.1525-1470.2012.01756.x. Epub 2012 Jul 2. PMID: 22747704 </br>3:Factors affecting efficacy of oral trimeprazine sedation for dental procedures in children: A retrospective study. Bello LL.Saudi Dent J. 2011 Apr;23(2):87-90. doi: 10.1016/j.sdentj.2011.01.004. Epub 2011 Feb 3. PMID: 23960504 Free PMC Article</br>4:Drop-to-drop solvent microextraction coupled with gas chromatography/mass spectrometry for rapid determination of trimeprazine in urine and blood of rats: application to pharmacokinetic studies. Agrawal K, Wu HF.Rapid Commun Mass Spectrom. 2007;21(20):3352-6. PMID: 17880040 </br>5:Determination of trimeprazine-facilitated sedation in children by hair analysis. Kintz P, Villain M, Cirimele V.J Anal Toxicol. 2006 Jul-Aug;30(6):400-2. PMID: 16872573 </br>6:A comparative study on the effects of oral amiodarone and trimeprazine, two in vitro retinyl ester hydrolase inhibitors, on the metabolic availability of vitamin A in rats. Schindler R, Fielenbach T, Rave G.Br J Nutr. 2005 Nov;94(5):675-83. PMID: 16277768 </br>7:[Value of trimeprazine among hypnotics in a psychiatric facility]. Mohammadi R, Gaudoneix-Taieb M, Armand-Branger S, Beauverie P, Poisson N.Encephale. 2000 Sep-Oct;26(5):75-80. French. PMID: 11192808 </br>8:Interaction of trimeprazine with cyclodextrins in aqueous solution. Lutka A, Koziara J.Acta Pol Pharm. 2000 Sep-Oct;57(5):369-74. PMID: 11126028 Free Article</br>9:A new powerful antibacterial synergistic combination of trimethoprim and trimeprazine. Guha Thakurta A, Mandal SK, Ganguly K, Dastidar SG, Chakrabarty AN.Acta Microbiol Immunol Hung. 2000;47(1):21-8. PMID: 10735187 </br>10:A multiple-baseline, double-blind evaluation of the effects of trimeprazine tartrate on infant sleep disturbance. France KG, Blampied NM, Wilkinson P.Exp Clin Psychopharmacol. 1999 Nov;7(4):502-13. PMID: 10609985 |
