For research use only. Not for therapeutic Use.
Trimetaphan camsilate is a drug that counteracts cholinergic transmission at the ganglion type of nicotinic receptors of the autonomic ganglia and therefore blocks both the sympathetic nervous system and the parasympathetic nervous system. It acts as a non-depolarizing competitive antagonist at the nicotinic acetylcholine receptor, is short-acting, and is given intravenously.
| Catalog Number | I009884 |
| CAS Number | 7187-66-8 (camsilate) |
| Synonyms | Trimethaphan; Trimetaphan camsilate; Trimetaphan camsilate (INN) or trimethaphan camsylate (USAN), trade name Arfonad.;1,3-dibenzyl-2-oxodecahydrothieno[1/’,2/’:1,2]thieno[3,4-d]imidazol-5-ium ((1R,4S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)meth |
| Molecular Formula | C32H40N2O5S2 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| InChI | InChI=1S/C22H25N2OS.C10H16O4S/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18;1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14/h1-6,8-11,19-21H,7,12-16H2;7H,3-6H2,1-2H3,(H,12,13,14)/q+1;/p-1/t;7-,10-/m.0/s1 |
| InChIKey | HALWUDBBYKMYPW-JAGIHPHKSA-M |
| SMILES | CC1(C)[C@H]2CC[C@]1(CS(=O)([O-])=O)C(C2)=O.O=C(N3CC4=CC=CC=C4)N(CC5=CC=CC=C5)C6C3C7CCC[S+]7C6 |
| Reference | </br> 1:Tono T, Ueki Y, Nagata N, Haruta A, Komune S. Effects of trimetaphan-induced deliberate hypotension on human cochlear blood flow. Acta Otolaryngol Suppl. 1998;539:40-3. PubMed PMID: 10095859.</br> 2: Higa K, Mori M, Shono S, Dan K. Trimetaphan may cause coronary artery spasm. Eur J Anaesthesiol. 1995 Sep;12(5):529-32. PubMed PMID: 8542864.</br> 3:Sha K, Furuya H, Yan S, Kuzumoto N, Furuki T, Okuda T. [Effects of nitroglycerin, prostaglandin E1, trimetaphan and nicardipine on systemic vascular resistance, pulmonary vascular resistance and pulmonary-systemic vascular resistance ratio in dogs]. Masui. 1995 Jul;44(7):944-9. Japanese. PubMed PMID: 7637184. |
