Trimetazidine dihydrochloride

• CAT Number: I001224
• CAS Number: 13171-25-0
• Molecular Formula: C14H22N2O3 • 2HCl
• Molecular Weight: 339.26
• Purity: ≥95%
• Synonyms: 1-[(2,3,4-trimethoxyphenyl)methyl]-piperazine, dihydrochloride
• Target: Autophagy
• Solubility: 10 mM in H2O
• Storage: -20°C
• IUPAC Name: 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dihydrochloride
• InChI: 1S/C14H22N2O3.2ClH/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16;;/h4-5,15H,6-10H2,1-3H3;2*1H
• InChIKey: VYFLPFGUVGMBEP-UHFFFAOYSA-N
• SMILES: COC1=C(C(=C(C=C1)CN2CCNCC2)OC)OC.Cl.Cl

Trimetazidine dihydrochloride (Cat No.: I001224) is a metabolic agent primarily used in the treatment of angina pectoris and ischemic heart disease. It works by improving myocardial efficiency, primarily through inhibiting fatty acid oxidation and promoting glucose metabolism in heart cells, which provides energy more efficiently under conditions of reduced oxygen supply. This mechanism helps protect heart muscle from ischemic damage. Trimetazidine is also explored for use in Parkinson’s disease due to its neuroprotective effects on dopaminergic neurons.