For research use only. Not for therapeutic Use.
Trimethoprim-d9 (CAS: 1189460-62-5), a high-quality pharmaceutical research compound designed for advanced antimicrobial and antibacterial studies. As a deuterated analog of Trimethoprim, it offers enhanced stability and improved pharmacokinetic properties. Trimethoprim-d9 is ideal for use in pharmacological and biochemical research, providing precise and reliable data for your studies. This high-purity compound ensures consistent results, aiding in the development of novel therapies for bacterial infections. Trusted by leading laboratories, Trimethoprim-d9 is your go-to solution for cutting-edge antimicrobial research. Unlock new possibilities in infection treatment with Trimethoprim-d9, where innovation meets reliability.
| CAS Number | 1189460-62-5 |
| Molecular Formula | C14H9D9N4O3 |
| Purity | ≥95% |
| Target | Anti-infection |
| IUPAC Name | 5-[[3,4,5-tris(trideuteriomethoxy)phenyl]methyl]pyrimidine-2,4-diamine |
| InChI | InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)/i1D3,2D3,3D3 |
| InChIKey | IEDVJHCEMCRBQM-GQALSZNTSA-N |
| SMILES | [2H]C([2H])([2H])OC1=CC(=CC(=C1OC([2H])([2H])[2H])OC([2H])([2H])[2H])CC2=CN=C(N=C2N)N |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Laskowska, E., et al., Trimethoprim induces heat shock proteins and protein aggregation in E. coli cells. Curr Microbiol, 2003. 47(4): p. 286-9. [3]. Brogden, R.N., et al., Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs, 1982. 23(6): p. 405-30. [4]. Xiaojian Wang, et al. A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo. Bioconjug Chem. 2018 May 16;29(5):1729-1735. |
