For research use only. Not for therapeutic Use.
Trimethoprim lactate（Cat No.:R004943）is an antibiotic used primarily to treat bacterial infections, particularly urinary tract infections and respiratory tract infections. It functions by inhibiting bacterial dihydrofolate reductase, an enzyme critical for synthesizing folate, thereby preventing the growth and reproduction of bacteria. The lactate formulation enhances solubility and bioavailability, making it suitable for oral administration. Trimethoprim is often combined with sulfamethoxazole in a synergistic approach, increasing efficacy against a broader range of pathogens. Its effectiveness and relatively low toxicity make it a commonly prescribed antibiotic in clinical practice.
| Catalog Number | R004943 |
| CAS Number | 23256-42-0 |
| Molecular Formula | C17H24N4O6 |
| Purity | ≥95% |
| Storage | 2-8 °C |
| IUPAC Name | 2-hydroxypropanoic acid;5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine |
| InChI | InChI=1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6) |
| InChIKey | IIZVTUWSIKTFKO-UHFFFAOYSA-N |
| SMILES | CC(C(=O)O)O.COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N |
| Reference | <p>Weir, D. G., and J. Scott. /Mechanism of the Antimicrobial Drug Trimethoprim Revisited./<em>PubMed</em> (2000): 2519-524. <em>www.ncbi.gov</em>. 14 Dec. 2000. Web. 21 Aug. 2012.</p><p>Kneifel W. and Leonhardt W., Testing of different antibiotics against Gram-positive and Gram-negative bacteria isolated from plant tissue culture. Plant Cell, Tissue and Organ Culture, Vol. 29, pp. 139-144, 1992.</p><p>Pollock K., Barfield D.G. and Shields R., The toxicity of antibiotics to plant cell cultures. Plant cell reports, Vol. 2, pp. 36-39, 1983.</p></span></p> |
