For research use only. Not for therapeutic Use.
<p>It is a neuronal voltage-dependent and GABA-gated Cl- channels blocker. It is also a non-competitive GABA antagonist and it causes epileptoform seizures.</p><br />Organophosphorous compound<!–C<SUB>6</SUB>H<SUB>11</SUB>O<SUB>4</SUB>P–>, synthetic</br><p>Cl- channel total blocking concentration: (IC<sub>100</sub>) ~ 50 nM (<em>Lymnaea stagnalis</em>);<br />(IC<sub>50</sub>) for [<sup>3</sup>H]-dihydropicrotoxin binding with rat brain membrane P2 fraction: 5.0 &mu;M (Ticku M.);<br /><br />(IC<sub>50</sub>) for [<sup>35</sup>S]-tert.butyl-thionebicyclophosphate binding with human brain membranes : 5.9 &mu;M (Casida J.);<br /> <br />experiments with [3H]-labelled GABA-competitive ligands (Muscimol, Funitrazepam) showed no influence of Etbicyphat up to 10 &mu;M.</p></br>
| Catalog Number | R029287 |
| CAS Number | 1005-93-2 |
| Synonyms | TMPP; 2-Ethyl-2-(Hydroxymethyl)-1,3-propanediol Cyclic Phosphate;?2-Ethyl-2-(hydroxymethyl)-1,3-propanediol Cyclic Phosphate;?4-Ethyl-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane 1-Oxide?4-Ethyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane 1-Oxide; Etbic |
| Molecular Formula | C6H11O4P |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| IUPAC Name | 4-ethyl-2,6,7-trioxa-1$l^{5} |
| InChI | InChI=1S/C6H11O4P/c1-2-6-3-8-11(7,9-4-6)10-5-6/h2-5H2,1H3 |
| InChIKey | BYEFHDZWRALTEN-UHFFFAOYSA-N |
| SMILES | CCC12COP(=O)(OC1)OC2 |
| Reference | – Bellet et al., <I>Science</I>.(1973) 182:1135-1136<br /><br />- Cooper G. H. et al., Eur. J. Med. Chem. (1978). 13:207-212<br /><br />- Fetisov et al., Biol. Membr. (1986) (Russian). 3(5):968-970<br /><br />- Squires et al., <I>Mol. Pharmacol.</I>(1983) 23:326-331<br /><br /><br /><br /> |
