Trimetrexate glucuronate

• CAT Number: I037525
• CAS Number: 82952-64-5
• Molecular Formula: C25H33N5O10
• Molecular Weight: 563.56
• Purity: 98%
• Synonyms: Trimetrexate glucuronate; DRG0183; DRG 0183; DRG-0183; CI898; CI-898; CI 898
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine;(2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexanoic acid
• InChI: InChI=1S/C19H23N5O3.C6H10O7/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3;7-1-2(8)3(9)4(10)5(11)6(12)13/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24);1-5,8-11H,(H,12,13)/t;2-,3+,4-,5-/m.0/s1
• InChIKey: ZCJXQWYMBJYJNB-LRDBBFHQSA-N
• SMILES: CC1=C(C=CC2=C1C(=NC(=N2)N)N)CNC3=CC(=C(C(=C3)OC)OC)OC.C(=O)[C@@H]([C@H]([C@@H]([C@@H](C(=O)O)O)O)O)O

Trimetrexate glucuronate（Cat No.:I037525）is an active metabolite of trimetrexate, a potent inhibitor of dihydrofolate reductase (DHFR), which plays a critical role in folate metabolism and DNA synthesis. This compound has shown efficacy in treating certain types of cancer, particularly in patients with reduced response to conventional methotrexate therapy. Trimetrexate glucuronate enhances the therapeutic effects of trimetrexate by improving its solubility and bioavailability. Ongoing research focuses on its pharmacokinetics, mechanisms of action, and potential applications in combination therapies to optimize treatment outcomes for various malignancies.

Reference

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