For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii.<br>IC50 Value:<br>Target: NF-kB; Apoptosis inducer<br>in vitro: Triptolide is a diterpene triepoxide with potent immunosuppressive and antiinflammatory properties. Triptolide is shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. Triptolide inhibits the proliferation and colony formation of tumor cells at extremely low concentrations (2-10 ng/mL). Triptolide has an inhibitory activity on breast, stomach and leukemia cell line HL-60 cells. Triptolide induces apoptosis in tumor cells by blocking NF-κB activation and sensitizing tumor cells for TNF-&alpha induced programmed cell death.<br>in vivo: bTriptolide synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor necrosis factor (TNF-α) induction of apoptosis in part through the suppression of c-IAP2 and c-IAP1 induction. Triptolide treatment for 2-3 weeks inhibits the growth of xenografts formed by four different tumor cell lines (B16 melanoma, MDA-435 breast cancer, TSU bladder cancer, and MGC80-3 gastric carcinoma), indicating that TPL has a broad spectrum of activity against tumors that contain both wild-type and mutant forms of p53. In addition, Triptolide inhibits experimental metastasis of B16F10 cells to the lungs and spleens of mice. Triptolide has in vitro and in vivo activities against mouse models of polycystic kidney disease. LD50: Mice 0.83mg/kg (i.v.).<br></p>
| Catalog Number | I003420 |
| CAS Number | 38748-32-2 |
| Synonyms | (6aS,7aS,8R,8aR,9aS,9bS,10aS,10bS)-8-hydroxy-8a-isopropyl-10b-methyl-1,5,5b,6,6a,8,8a,9a,9b,10b-decahydrotris(oxireno)[2/’,3/’:4b,5;2/’/’,3/’/’:6,7;2/’/’/’,3/’/’/’:8a,9]phenanthro[1,2-c]furan-3(2H)-one |
| Molecular Formula | C₂₀H₂₄O₆ |
| Purity | ≥95% |
| Target | NF-κB |
| Solubility | DMSO: ≥ 33 mg/mL |
| Storage | 3 years -20C powder |
| InChI | InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1 |
| InChIKey | DFBIRQPKNDILPW-CIVMWXNOSA-N |
| SMILES | CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C |
| Reference | </br>1:Self-protection against triptolide-induced toxicity in human hepatic cells via Nrf2-ARE-NQO1 pathway. Zhou LL, Zhou C, Liang XW, Feng Z, Liu ZP, Wang HL, Zhou XP.Chin J Integr Med. 2017 May 18. doi: 10.1007/s11655-017-2546-6. [Epub ahead of print] PMID: 28523535 </br>2:Glycyrrhetinic Acid Accelerates the Clearance of Triptolide through P-gp In Vitro. Li Z, Yan M, Cao L, Fang P, Guo Z, Hou Z, Zhang B.Phytother Res. 2017 May 16. doi: 10.1002/ptr.5831. [Epub ahead of print] PMID: 28509400 </br>3:EFFECT OF TRIPTOLIDE ON PROLIFERATION AND APOPTOSIS OF ANGIOTENSIN II-INDUCED CARDIAC FIBROBLASTS <i>IN VITRO:</i> A PRELIMINARY STUDY. Liu M, Yeh J, Huang Y, Redondo A, Ke J, Yao J, Tan G, Tang W, Chen J.Afr J Tradit Complement Altern Med. 2016 Nov 23;14(1):145-154. doi: 10.21010/ajtcam.v14i1.16. eCollection 2017. PMID: 28480392 </br>4:STUDIES ON THE INTERACTION BETWEEN TRIPTOLIDE AND BOVINE SERUM ALBUMIN (BSA) BY SPECTROSCOPIC AND MOLECULAR MODELING METHODS. Wang H, Shi H, Pang J, Song X, Xu C, Sun Z.Afr J Tradit Complement Altern Med. 2016 Sep 29;13(6):121-129. doi: 10.21010/ajtcam.v13i6.17. eCollection 2016. PMID: 28480368 </br>5:Supplementation with Triptolide Increases Resistance to Environmental Stressors and Lifespan in C. elegans. Kim SJ, Beak SM, Park SK.J Food Sci. 2017 May 4. doi: 10.1111/1750-3841.13720. [Epub ahead of print] PMID: 28471052 </br>6:Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling. Song JM, Molla K, Anandharaj A, Cornax I, O Sullivan MG, Kirtane AR, Panyam J, Kassie F.Oncotarget. 2017 Apr 18;8(16):26927-26940. doi: 10.18632/oncotarget.15879. PMID: 28460475 Free PMC Article</br>7:Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy. Lin C, Wong BCK, Chen H, Bian Z, Zhang G, Zhang X, Kashif Riaz M, Tyagi D, Lin G, Zhang Y, Wang J, Lu A, Yang Z.Sci Rep. 2017 Apr 20;7(1):1097. doi: 10.1038/s41598-017-00957-4. PMID: 28428618 Free PMC Article</br>8:[The role of FOXO3a-Bim signaling in triptolide induced bladder cancer T24 cells apoptosis]. Yang LL, Wang XY, Zheng LY, Fang SJ, Xu M, Zhao ZW, Ji JS.Zhonghua Yi Xue Za Zhi. 2017 Apr 18;97(15):1187-1190. doi: 10.3760/cma.j.issn.0376-2491.2017.15.016. Chinese. PMID: 28427129 </br>9:Triptolide mitigates radiation-induced pneumonitis via inhibition of alveolar macrophages and related inflammatory molecules. Chen C, Yang S, Zhang M, Zhang Z, Zhang SB, Wu B, Hong J, Zhang W, Lin J, Okunieff P, Zhang L.Oncotarget. 2017 Mar 22. doi: 10.18632/oncotarget.16456. [Epub ahead of print] PMID: 28415830 Free Article</br>10:Toxicity of triptolide and the molecular mechanisms involved. Xi C, Peng S, Wu Z, Zhou Q, Zhou J.Biomed Pharmacother. 2017 Jun;90:531-541. doi: 10.1016/j.biopha.2017.04.003. Epub 2017 Apr 10. Review. PMID: 28402922 |
