For research use only. Not for therapeutic Use.
Tropicamide is an antimuscarinic drug that produces short acting mydriasis (dilation of the pupil) and cycloplegia when applied as eye drops. It is used to allow better examination of the lens, vitreous humor, and retina. Due to its relatively short duration of effect (4–8 hours), it is typically used during eye examinations such as the dilated fundus examination, but it may also be used before or after eye surgery. Cycloplegic drops are often also used to treat anterior uveitis, decreasing risk of posterior synechiae and decreasing inflammation in the anterior chamber of the eye.
| Catalog Number | A001220 |
| CAS Number | 1508-75-4 |
| Synonyms | NA |
| Molecular Formula | C17H20N2O2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | 3 years -20C powder |
| InChIKey | BGDKAVGWHJFAGW-UHFFFAOYSA-N |
| Reference | </br>1:Cycloplegic Refraction in Hyperopic Children: Effectiveness of a 0.5% Tropicamide and 0.5% Phenylephrine Addition to 1% Cyclopentolate Regimen. Yoo SG, Cho MJ, Kim US, Baek SH.Korean J Ophthalmol. 2017 Apr 24. doi: 10.3341/kjo.2016.0007. [Epub ahead of print] PMID: 28471102 Free Article</br>2:Early signal of diverted use of tropicamide eye drops in France. Ponté C, Pi C, Palmaro A, Jouanjus E, Lapeyre-Mestre M; French Addictovigilance Network..Br J Clin Pharmacol. 2017 Feb 27. doi: 10.1111/bcp.13272. [Epub ahead of print] PMID: 28239898 </br>3:Correction: Time-Course of Changes in Choroidal Thickness after Complete Mydriasis Induced by Compound Tropicamide in Children. PLOS ONE Staff..PLoS One. 2017 Feb 6;12(2):e0171924. doi: 10.1371/journal.pone.0171924. eCollection 2017. PMID: 28166303 Free PMC Article</br>4:Higher-Order Aberrations After Cyclopentolate, Tropicamide, and Artificial Tear Drops Application in Normal Eyes. Amirshekarizadeh N, Hashemi H, Jafarzadehpur E, Mirzajani A, Yekta A, Khabazkhoob M.Eye Contact Lens. 2016 Sep 30. [Epub ahead of print] PMID: 27749472 </br>5:Time-Course of Changes in Choroidal Thickness after Complete Mydriasis Induced by Compound Tropicamide in Children. Li Z, Zeng J, Jin W, Long W, Lan W, Yang X.PLoS One. 2016 Sep 13;11(9):e0162468. doi: 10.1371/journal.pone.0162468. eCollection 2016. Erratum in: PLoS One. 2017 Feb 6;12 (2):e0171924. PMID: 27622495 Free PMC Article</br>6:Combination of 5% phenylephrine and 0.5% tropicamide eyedrops for pupil dilation in neonates is twice as effective as 0.5% tropicamide eyedrops alone. Lux AL, Degoumois A, Barjol A, Mouriaux F, Denion E.Acta Ophthalmol. 2017 Mar;95(2):165-169. doi: 10.1111/aos.13175. Epub 2016 Aug 13. PMID: 27519933 </br>7:Cycloplegic effect of atropine compared with cyclopentolate-tropicamide combination in children with hypermetropia. Sani RY, Hassan S, Habib SG, Ifeanyichukwu EP.Niger Med J. 2016 May-Jun;57(3):173-7. doi: 10.4103/0300-1652.184065. PMID: 27397958 Free PMC Article</br>8:[The distribution of tropicamide in the body of warm-blooded animals after its intragastric administration]. Shormanov VK, Pravdyuk MF, Cheked MV, Barannikova VV.Sud Med Ekspert. 2016 Mar-Apr;59(2):27-34. Russian. PMID: 27070036 </br>9:Cubic liquid crystalline nanoparticles: optimization and evaluation for ocular delivery of tropicamide. Verma P, Ahuja M.Drug Deliv. 2016 Oct;23(8):3043-3054. Epub 2016 Feb 15. PMID: 26878398 </br>10:Pupil response to tropicamide following corneal crosslinking. Kymionis GD, Paraskevopoulos TA, Liakopoulos DA, Grentzelos MA, Kouroupaki AI, Tsoulnaras KI, Panagopoulou SI, Mazzotta C, Detorakis ET.Eur J Ophthalmol. 2016 Aug 4;26(5):394-7. doi: 10.5301/ejo.5000758. Epub 2016 Jan 28. PMID: 26833233 |
