For research use only. Not for therapeutic Use.
Tropifexor(Cat No.:I009471)is a potent, selective agonist of the farnesoid X receptor (FXR), pivotal for liver health and metabolic function. By targeting FXR, Tropifexor enhances bile acid regulation, reducing liver inflammation and fibrosis. Its selective mechanism makes it a promising candidate for non-alcoholic steatohepatitis (NASH) treatment and other liver disorders, potentially offering improved outcomes with fewer side effects. Tropifexor’s efficacy in modulating liver enzymes and reducing fat accumulation supports its role in advancing treatments for chronic liver diseases, making it valuable in ongoing hepatic research and therapeutic development.
Catalog Number | I009471 |
CAS Number | 1383816-29-2 |
Synonyms | Tropifexor.;2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid |
Molecular Formula | C29H25F4N3O5S |
Purity | ≥95% |
Target | Autophagy |
Solubility | Soluble in DMSO |
Storage | 0 - 4 °C for short term, or -20 °C for long term |
IUPAC Name | 2-[(1R,5S)-3-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid |
InChI | InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12-18(11-16)39-13-20-24(35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31,32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18? |
InChIKey | VYLOOGHLKSNNEK-JWTNVVGKSA-N |
SMILES | C1CC1C2=C(C(=NO2)C3=CC=CC=C3OC(F)(F)F)COC4CC5CCC(C4)N5C6=NC7=C(C=C(C=C7S6)C(=O)O)F |
Reference | 1. J Med Chem. 2017 Dec 8. doi: 10.1021/acs.jmedchem.7b00907. [Epub ahead of print] |