Troviridine

• CAT Number: I001842
• CAS Number: 149488-17-5
• Molecular Formula: C₁₃H₁₃BrN₄S
• Molecular Weight: 337.24
• Purity: ≥95%
• Target: HIV-1
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 7 nM
• InChI: InChI=1S/C13H13BrN4S/c14-10-4-5-12(17-9-10)18-13(19)16-8-6-11-3-1-2-7-15-11/h1-5,7,9H,6,8H2,(H2,16,17,18,19)
• InChIKey: HOCFDYZWQYGULA-UHFFFAOYSA-N
• SMILES: C1=CC=NC(=C1)CCNC(=S)NC2=NC=C(C=C2)Br

Troviridine(CAT: I001842) is a non-nucleoside HIV-1 reverse transcriptase inhibitor. It belongs to a class of compounds that specifically target the reverse transcriptase enzyme of the human immunodeficiency virus (HIV-1). These inhibitors work by binding to the reverse transcriptase enzyme and blocking its activity, thus preventing the conversion of viral RNA into DNA, which is necessary for the replication of the virus. By inhibiting this crucial step in the viral life cycle, troviridine and similar compounds can help suppress the replication of HIV-1 and potentially slow down the progression of HIV/AIDS.

Reference

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Laumond G, Aubertin AM. Synthesis and anti-HIV activity of [d4U]-[trovirdine
analogue] and [d4T]-[trovirdine analogue] heterodimers as inhibitors of HIV-1
reverse transcriptase. Nucleosides Nucleotides Nucleic Acids.
2002;21(8-9):505-33. PubMed PMID: 12484448.
2: Zhang H, Vrang L, Bäckbro K, Lind P, Sahlberg C, Unge T, Oberg B. Inhibition
of human immunodeficiency virus type 1 wild-type and mutant reverse
transcriptases by the phenyl ethyl thiazolyl thiourea derivatives trovirdine and
MSC-127. Antiviral Res. 1995 Dec;28(4):331-42. PubMed PMID: 8669892.
3: Sugeac E, Fossey C, Ladurée D, Schmidt S, Laumond G, Aubertin AM. Synthesis
and anti-HIV activity of some heterodimers [NRTI]-glycyl-succinyl-[trovirdine
analogue] of known HIV-1 reverse transcriptase inhibitors. J Enzyme Inhib Med
Chem. 2003 Apr;18(2):175-86. PubMed PMID: 12943202.