For research use only. Not for therapeutic Use.
TRPM8 antagonist 3 is a novel TRPM8 blocker with an IC50 value of 11 nM.
| Catalog Number | I045172 |
| CAS Number | 2102179-29-1 |
| Synonyms | [4-hydroxy-2-(2-hydroxyphenyl)-1,3-thiazol-5-yl]-(1,2-oxazolidin-2-yl)methanone |
| Molecular Formula | C13H12N2O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C13H12N2O4S/c16-9-5-2-1-4-8(9)12-14-11(17)10(20-12)13(18)15-6-3-7-19-15/h1-2,4-5,16-17H,3,6-7H2 |
| InChIKey | BKUQCBLRBYEPFS-UHFFFAOYSA-N |
| SMILES | C1CN(OC1)C(=O)C2=C(N=C(S2)C3=CC=CC=C3O)O |
| Reference | [1]. Bianchini G, et al. Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through pKa and LogD Modulation. J Med Chem. 2021 Nov 25;64(22):16820-16837. |
