TRPV1 antagonist CX-3

• CAT Number: I047737
• CAS Number: 2998942-96-2
• Molecular Formula: C26H24O4
• Molecular Weight: 400.47
• Purity: ≥95%

TRPV1 antagonist CX-3 is a first-in-class highly selective TRPV1 antagonist with an IC50 value of 26.2 nM. CX-3 exhibited equivalent TRPV1 antagonistic activity with classical TRPV1 antagonist BCTC in vitro, and exerted better analgesic activity in vivo than that of BCTC in the formalin induced inflammatory pain model without hyperthermia risk. Moreover, CX-3 exhibited robust glucose-lowering effects and showed high selectivity over other ion channels.
Keywords: TRPV1 antagonist CX-3 | Supplier | TRPV1 antagonist | CX3 | CX 3 | CAS [2998942-96-2] | Non Selective (Cations) | TRPV1 | Antagonist | Ion Channels | Analgesia | Hypoglycemia | Diabetes | Neuropathic pain

Reference

C Liu et al. Discovery of first-in-class highly selective TRPV1 antagonists with dual analgesic and hypoglycemic effects. Bioorg Med Chem. 2024 Jun 1;107(0):117750.