TRPV2-selective blocker 1

For research use only. Not for therapeutic Use.

  • CAT Number: I040520
  • CAS Number: 2242724-49-6
  • Molecular Formula: C15H18OS2
  • Molecular Weight: 278.43
  • Purity: ≥95%
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TRPV2-selective blocker 1 (compound IV2-1) is a selective TRPV2 channel blocker with an IC50 of 6.3 μM. TRPV2-selective blocker 1 does not affect TRPV1, TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 also inhibits TRPV2-mediated Ca2+ influx in macrophages, and inhibits macrophage phagocytosis[1].


Catalog Number I040520
CAS Number 2242724-49-6
Synonyms

5-(1,3-dithiolan-2-ylidene)-4-methyl-5-phenylpentan-2-one

Molecular Formula C15H18OS2
Purity ≥95%
InChI InChI=1S/C15H18OS2/c1-11(10-12(2)16)14(15-17-8-9-18-15)13-6-4-3-5-7-13/h3-7,11H,8-10H2,1-2H3
InChIKey RCALJRZMLQRHLX-UHFFFAOYSA-N
SMILES CC(CC(=O)C)C(=C1SCCS1)C2=CC=CC=C2
Reference

[1]. Rick Raudszus, et al. Pharmacological inhibition of TRPV2 attenuates phagocytosis and lipopolysaccharide-induced migration of primary macrophages. Br J Pharmacol. 2023 Nov;180(21):2736-2749.
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