For research use only. Not for therapeutic Use.
TRPV2-selective blocker 1 (compound IV2-1) is a selective TRPV2 channel blocker with an IC50 of 6.3 μM. TRPV2-selective blocker 1 does not affect TRPV1, TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 also inhibits TRPV2-mediated Ca2+ influx in macrophages, and inhibits macrophage phagocytosis[1].
Catalog Number | I040520 |
CAS Number | 2242724-49-6 |
Synonyms | 5-(1,3-dithiolan-2-ylidene)-4-methyl-5-phenylpentan-2-one |
Molecular Formula | C15H18OS2 |
Purity | ≥95% |
InChI | InChI=1S/C15H18OS2/c1-11(10-12(2)16)14(15-17-8-9-18-15)13-6-4-3-5-7-13/h3-7,11H,8-10H2,1-2H3 |
InChIKey | RCALJRZMLQRHLX-UHFFFAOYSA-N |
SMILES | CC(CC(=O)C)C(=C1SCCS1)C2=CC=CC=C2 |
Reference | [1]. Rick Raudszus, et al. Pharmacological inhibition of TRPV2 attenuates phagocytosis and lipopolysaccharide-induced migration of primary macrophages. Br J Pharmacol. 2023 Nov;180(21):2736-2749. |