For research use only. Not for therapeutic Use.
Lats-IN-1（Cat No.:L001542）is a potent inhibitor of Lats1 and Lats2 kinases, effectively blocking their activity by competing with ATP binding. By inhibiting Lats1 and Lats2, Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues. This compound’s ability to modulate Lats kinases and Yap signaling pathways makes it a valuable tool in research, shedding light on the regulation of cell growth and proliferation. Its use may have implications for understanding tissue development and regeneration and could potentially lead to therapeutic applications in tissue repair and regeneration.
| Catalog Number | L001542 |
| CAS Number | 1424635-83-5 |
| Molecular Formula | C18H14N4OS |
| Purity | ≥95% |
| Target | YAP |
| Storage | Store at -20°C |
| IUPAC Name | N-(3-benzyl-1,3-thiazol-2-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide |
| InChI | InChI=1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20) |
| InChIKey | VTXBMVZVPUSAJF-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CN2C=CSC2=NC(=O)C3=CNC4=C3C=CC=N4 |
