TRV-120027

• CAT Number: I009896
• CAS Number: 1234510-46-3
• Molecular Formula: C43H67N13O10
• Molecular Weight: 926.07
• Purity: ≥95%
• Synonyms: (2R)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]propanoic acid
• InChI: InChI=1S/C43H67N13O10/c1-7-24(4)35(40(63)53-31(19-27-20-47-22-49-27)41(64)56-17-9-11-32(56)38(61)50-25(5)42(65)66)55-37(60)30(18-26-12-14-28(57)15-13-26)52-39(62)34(23(2)3)54-36(59)29(51-33(58)21-46-6)10-8-16-48-43(44)45/h12-15,20,22-25,29-32,34-35,46,57H,7-11,16-19,21H2,1-6H3,(H,47,49)(H,50,61)(H,51,58)(H,52,62)(H,53,63)(H,54,59)(H,55,60)(H,65,66)(H4,44,45,48)/t24-,25+,29-,30-,31-,32-,34-,35-/m0/s1
• InChIKey: XIEWFECSPPTVQN-KMIMAYJXSA-N
• SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(C)C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)CNC

TRV-120027 (also known as oliceridine) is a novel G-protein biased ligand at the μ-opioid receptor, developed as an analgesic for the treatment of acute pain. Unlike traditional opioids, which activate both G-protein signaling and β-arrestin pathways, TRV-120027 selectively engages the G-protein pathway, which is associated with pain relief, while minimizing activation of the β-arrestin pathway, which is linked to adverse effects like respiratory depression and constipation. This selective activation aims to provide effective pain relief with a reduced risk of typical opioid side effects.