Trypanothione

• CAT Number: R030617
• CAS Number: 96304-42-6
• Molecular Formula: C27H47N9O10S2
• Molecular Weight: 721.85
• Purity: ≥95%
• Synonyms: Trypanothione disulfide; Oxidized trypanothione; dethiotrypanothione.
• Storage: Desiccate at RT
• IUPAC Name: (2S)-2-amino-5-[[(4R,23R)-4-[[(4S)-4-amino-4-carboxybutanoyl]amino]-5,8,19,22-tetraoxo-1,2-dithia-6,9,13,18,21-pentazacyclotetracos-23-yl]amino]-5-oxopentanoic acid
• InChI: InChI=1S/C27H47N9O10S2/c28-16(26(43)44)4-6-20(37)35-18-14-47-48-15-19(36-21(38)7-5-17(29)27(45)46)25(42)34-13-23(40)32-11-3-9-30-8-1-2-10-31-22(39)12-33-24(18)41/h16-19,30H,1-15,28-29H2,(H,31,39)(H,32,40)(H,33,41)(H,34,42)(H,35,37)(H,36,38)(H,43,44)(H,45,46)/t16-,17-,18-,19-/m0/s1
• InChIKey: LZMSXDHGHZKXJD-VJANTYMQSA-N
• SMILES: C1CCNC(=O)CNC(=O)C(CSSCC(C(=O)NCC(=O)NCCCNC1)NC(=O)CCC(C(=O)O)N)NC(=O)CCC(C(=O)O)N

Trypanothione（Cat No.:R030617）is a unique thiol compound found in trypanosomatid parasites, such as those causing Chagas disease and sleeping sickness. It consists of two glutathione molecules linked by a spermidine moiety. Trypanothione plays a crucial role in the parasite’s defense against oxidative stress and in maintaining redox balance. It is essential for the survival and virulence of these parasites, making it a key target for anti-parasitic drug development. By inhibiting trypanothione metabolism, researchers aim to develop effective treatments for diseases caused by trypanosomatid infections, offering hope for improved therapies.