For research use only. Not for therapeutic Use.
TT-10 (TAZ-K) is an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity. TT-10 can be used for the research of heart diseases accompanied by cardiomyocyte loss[1].
TT-10 (48 h) markedly promotes cell cycle activation and increased cell division of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (hiPSCMs)[1].
| Catalog Number | I037579 |
| CAS Number | 2230640-94-3 |
| Synonyms | [4-amino-2-(prop-2-enylamino)-1,3-thiazol-5-yl]-(5-fluorothiophen-2-yl)methanone |
| Molecular Formula | C11H10FN3OS2 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H10FN3OS2/c1-2-5-14-11-15-10(13)9(18-11)8(16)6-3-4-7(12)17-6/h2-4H,1,5,13H2,(H,14,15) |
| InChIKey | GVYPHJQPOHDZEI-UHFFFAOYSA-N |
| SMILES | C=CCNC1=NC(=C(S1)C(=O)C2=CC=C(S2)F)N |
| Reference | [1]. Masamichi Ito, et al. Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes. J Mol Cell Cardiol. 2019 Mar;128:90-95. |
