TT-232

• CAT Number: M095061
• CAS Number: 147159-51-1
• Molecular Formula: C45H58N10O9S2
• Molecular Weight: 947.13
• Purity: ≥95%
• Synonyms: (4R,7S,10R,13S,16R)-7-(4-aminobutyl)-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-16-[[(2R)-2-amino-3-phenylpropanoyl]amino]-13-[(4-hydroxyphenyl)methyl]-10-(1H-indol-3-ylmethyl)-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetrazacycloheptadecane-4-carboxamide
• InChI: InChI=1S/C45H58N10O9S2/c1-25(56)38(39(48)58)55-45(64)37-24-66-65-23-36(53-40(59)31(47)19-26-9-3-2-4-10-26)44(63)51-34(20-27-14-16-29(57)17-15-27)42(61)52-35(21-28-22-49-32-12-6-5-11-30(28)32)43(62)50-33(41(60)54-37)13-7-8-18-46/h2-6,9-12,14-17,22,25,31,33-38,49,56-57H,7-8,13,18-21,23-24,46-47H2,1H3,(H2,48,58)(H,50,62)(H,51,63)(H,52,61)(H,53,59)(H,54,60)(H,55,64)/t25-,31-,33+,34+,35-,36+,37+,38+/m1/s1
• InChIKey: SNAJPQVDGYDQSW-DYCFWDQMSA-N
• SMILES: C[C@H]([C@@H](C(=O)N)NC(=O)[C@@H]1CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)[C@@H](CC5=CC=CC=C5)N)O

TT-232（Cat No.:M095061）is a synthetic peptide designed to target and inhibit the interaction of certain proteins involved in tumor growth and immune evasion. Specifically, it acts as an antagonist to the NKG2D receptor-ligand pathway, which plays a crucial role in immune surveillance and the body’s ability to detect and destroy cancer cells. By blocking this interaction, TT-232 enhances the immune system’s response against tumors, potentially improving the efficacy of cancer immunotherapies. It is being studied in preclinical and clinical settings as a potential treatment for various malignancies, especially those with immune resistance.