For research use only. Not for therapeutic Use.
TTA-Q6 is a selective T-type Ca2+ channel antagonist, which can be used in the research of neurological disease[1].
TTA-Q6 is a selective T-type Ca2+ channel antagonist, with 14 nM and 590 nM in FLIPR depolarized assaay and FLIPR hyperpolarized assay[1].
| Catalog Number | I020135 |
| CAS Number | 910484-28-5 |
| Synonyms | 4-[(4S)-6-chloro-4-cyclopropyl-2-oxo-3-(2,2,2-trifluoroethyl)-1H-quinazolin-4-yl]benzonitrile |
| Molecular Formula | C20H15ClF3N3O |
| Purity | ≥95% |
| InChI | InChI=1S/C20H15ClF3N3O/c21-15-7-8-17-16(9-15)20(14-5-6-14,13-3-1-12(10-25)2-4-13)27(18(28)26-17)11-19(22,23)24/h1-4,7-9,14H,5-6,11H2,(H,26,28)/t20-/m1/s1 |
| InChIKey | OVRNWJYZCIAMGV-HXUWFJFHSA-N |
| SMILES | C1CC1C2(C3=C(C=CC(=C3)Cl)NC(=O)N2CC(F)(F)F)C4=CC=C(C=C4)C#N |
| Reference | [1]. Schlegel KA, et al. Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5147-52. |
