For research use only. Not for therapeutic Use.
TTP-8307（Cat No.:I016409）is a selective and potent inhibitor of c-Met, a receptor tyrosine kinase involved in cell growth, survival, and metastasis. By blocking the activation of c-Met, TTP-8307 disrupts signaling pathways associated with tumor proliferation and angiogenesis. It exhibits promising anticancer activity, particularly in tumors with aberrant c-Met expression or overactivation. TTP-8307 is a valuable tool in oncology research for studying c-Met-driven cancers and resistance mechanisms in targeted therapies. Its role in exploring novel therapeutic strategies highlights its potential in advancing precision medicine for cancer treatment.
| CAS Number | 950225-08-8 |
| Molecular Formula | C₂₇H₂₁FN₄O |
| Purity | ≥95% |
| Target | Cell Cycle/DNA Damage |
| IUPAC Name | N-[(1R)-1-(4-fluorophenyl)ethyl]-3-(2-isoquinolin-3-yl-1H-imidazol-5-yl)benzamide |
| InChI | InChI=1S/C27H21FN4O/c1-17(18-9-11-23(28)12-10-18)31-27(33)21-8-4-7-20(13-21)25-16-30-26(32-25)24-14-19-5-2-3-6-22(19)15-29-24/h2-17H,1H3,(H,30,32)(H,31,33)/t17-/m1/s1 |
| InChIKey | SIBDJDZVNXVLEX-QGZVFWFLSA-N |
| SMILES | C[C@H](C1=CC=C(C=C1)F)NC(=O)C2=CC=CC(=C2)C3=CN=C(N3)C4=CC5=CC=CC=C5C=N4 |
| Reference | [1]. De Palma AM, et al. Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307. Antimicrob Agents Chemother. 2009 May;53(5):1850-7.<br>[2]. Albulescu L, et al. Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Res. 2017 Apr;140:37-44. |
