For research use only. Not for therapeutic Use.
Tubacin（Cat No.:I003961）is a selective inhibitor of the enzyme tubulin deacetylase, specifically targeting histone deacetylase 6 (HDAC6). By inhibiting HDAC6, tubacin promotes the acetylation of tubulin, which enhances microtubule stability and disrupts the function of cellular processes such as cell motility and protein degradation. This compound has demonstrated potential in preclinical studies for treating various cancers and neurodegenerative diseases by modulating the cellular response to stress and promoting apoptosis in cancer cells. Ongoing research aims to further elucidate its mechanisms of action and explore its therapeutic applications in oncology and neurobiology.
| Catalog Number | I003961 |
| CAS Number | 537049-40-4 |
| Synonyms | N-[4-[(2R,4R,6S)-4-[(4,5-diphenyl-1,3-oxazol-2-yl)sulfanylmethyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N/’-hydroxyoctanediamide |
| Molecular Formula | C₄₁H₄₃N₃O₇S |
| Purity | ≥95% |
| Target | HDAC |
| Solubility | DMSO: 10 mM |
| Storage | Store at -20°C |
| InChI | InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H, |
| InChIKey | BHUZLJOUHMBZQY-YXQOSMAKSA-N |
| SMILES | C1C(OC(OC1C2=CC=C(C=C2)CO)C3=CC=C(C=C3)NC(=O)CCCCCCC(=O)NO)CSC4=NC(=C(O4)C5=CC=CC=C5)C6=CC=CC=C6 |
| Reference | </br>1:Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. Lu CY, Chang YC, Hua CH, Chuang C, Huang SH, Kung SH, Hour MJ, Lin CW.Int J Mol Sci. 2017 May 1;18(5). pii: E954. doi: 10.3390/ijms18050954. PMID: 28468311 Free Article</br>2:The HDAC6 Inhibitor Tubacin Induces Release of CD133<sup>+</sup> Extracellular Vesicles from Cancer Cells. Chao OS, Chang TC, Di Bella MA, Alessandro R, Anzanello F, Rappa G, Goodman OB, Lorico A.J Cell Biochem. 2017 Apr 27. doi: 10.1002/jcb.26095. [Epub ahead of print] PMID: 28452069 </br>3:[Tubacin promotes Foxp3 expression and suppressive function of mouse CD4+;CD25+; regulatory T cells]. Zhao S, Chen Z, Yu D, Tang M, Zhang W.Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016 Mar;32(3):339-42. Chinese. PMID: 26927553 </br>4:The histone deacetylase-6 inhibitor tubacin directly inhibits de novo sphingolipid biosynthesis as an off-target effect. Siow D, Wattenberg B.Biochem Biophys Res Commun. 2014 Jul 4;449(3):268-71. doi: 10.1016/j.bbrc.2014.05.016. Epub 2014 May 14. PMID: 24835950 </br>5:Tubacin prevents neuronal migration defects and epileptic activity caused by rat Srpx2 silencing in utero. Salmi M, Bruneau N, Cillario J, Lozovaya N, Massacrier A, Buhler E, Cloarec R, Tsintsadze T, Watrin F, Tsintsadze V, Zimmer C, Villard C, Lafitte D, Cardoso C, Bao L, Lesca G, Rudolf G, Muscatelli F, Pauly V, Khalilov I, Durbec P, Ben-Ari Y, Burnashev N, Represa A, Szepetowski P.Brain. 2013 Aug;136(Pt 8):2457-73. doi: 10.1093/brain/awt161. Epub 2013 Jul 5. PMID: 23831613 </br>6:Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells. Aldana-Masangkay GI, Rodriguez-Gonzalez A, Lin T, Ikeda AK, Hsieh YT, Kim YM, Lomenick B, Okemoto K, Landaw EM, Wang D, Mazitschek R, Bradner JE, Sakamoto KM.Leuk Lymphoma. 2011 Aug;52(8):1544-55. doi: 10.3109/10428194.2011.570821. Epub 2011 Jun 23. PMID: 21699378 Free PMC Article</br>7:Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis. Kawada J, Zou P, Mazitschek R, Bradner JE, Cohen JI.J Biol Chem. 2009 Jun 19;284(25):17102-9. doi: 10.1074/jbc.M809090200. Epub 2009 Apr 22. PMID: 19386607 Free PMC Article |
