Tubastatin A Hydrochloride

• CAT Number: I001190
• CAS Number: 1310693-92-5
• Molecular Formula: C20H21N3O2.HCl
• Molecular Weight: 371.86
• Purity: ≥95%
• Synonyms: N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide;hydrochloride
• Target: Cell Cycle/DNA Damage
• Solubility: DMSO: ≤ 10.8 mg/mL
• Storage: 3 years -20C powder
• IC50: 15 nM
• InChI: InChI=1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H
• InChIKey: LJTSJTWIMOGKRJ-UHFFFAOYSA-N
• SMILES: CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO.Cl

Tubastatin A hydrochloride（Cat No.:I001190）is a selective inhibitor of histone deacetylases (HDACs), particularly HDAC6. It plays a crucial role in regulating gene expression and protein degradation, which can influence various cellular processes, including cell survival and differentiation. Researchers are investigating its potential therapeutic applications in cancer and neurodegenerative diseases, as inhibiting HDAC6 may promote neuroprotection and enhance the degradation of misfolded proteins. The hydrochloride form improves solubility and stability for pharmaceutical use. Tubastatin A’s unique mechanism makes it a promising candidate for targeted therapies in oncology and neurology.

Reference

[1]. Kyle V. Butler et al. Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A J. Am. Chem. Soc., 2010, 132 (31), pp 10842-10846
[2]. Constantin d/’Ydewalle et al. HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease Nature Medicine 17, 968-974 (2011)
[3]. Butler KV, Kalin J, Brochier C, Vistoli G, Langley B, Kozikowski AP.,Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.,J Am Chem Soc. 2010 Aug 11;132(31):10842-6.
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[5]. Kappeler KV, Zhang J, Dinh TN, Strom JG, Chen QM.,Histone deacetylase 6 associates with ribosomes and regulates de novo protein translation during arsenite stress.,Toxicol Sci. 2012 May;127(1):246-55. Epub 2012 Feb 23.