Tubastatin A

• CAT Number: R050536
• CAS Number: 1239262-52-2
• Molecular Formula: C₂₀H₂₁N₃O₂.HCl
• Molecular Weight: 371.86
• Purity: ≥95%
• Synonyms: N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide 2,2,2-Trifluoroacetate
• Storage: -20°C
• InChI: InChI=1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H
• InChIKey: LJTSJTWIMOGKRJ-UHFFFAOYSA-N
• SMILES: CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO.Cl

Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-<wbr></wbr>fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM). Tubastatin A induces α-<wbr></wbr>tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-<wbr></wbr>dependent neuronal protection of primary cortical neuron cultures at 5-<wbr></wbr>10 μM.