Tubastatin TFA salt

• CAT Number: I037589
• CAS Number: 1239034-70-8
• Molecular Formula: C22H22F3N3O4
• Molecular Weight: 449.43
• Purity: 98%
• Synonyms: Tubastatin TFA salt
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: methyl 4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzoate
• InChI: InChI=1S/C21H22N2O2/c1-22-12-11-20-18(14-22)17-5-3-4-6-19(17)23(20)13-15-7-9-16(10-8-15)21(24)25-2/h3-10H,11-14H2,1-2H3
• InChIKey: RMAYYLGDIMEEOS-UHFFFAOYSA-N
• SMILES: CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)OC

Tubastatin TFA salt (Cat No.:I037589) is a highly potent inhibitor of histone deacetylase 6 (HDAC6). It exhibits strong selectivity for HDAC6 over other HDAC isoforms. HDAC6 is primarily responsible for the deacetylation of non-histone proteins, including α-tubulin. By inhibiting HDAC6, Tubastatin TFA salt promotes tubulin acetylation, which can affect cellular processes such as microtubule dynamics, cell migration, and protein degradation. Tubastatin TFA salt has been widely used as a tool compound in research studies to investigate the role of HDAC6 and its potential therapeutic applications in various diseases.