For research use only. Not for therapeutic Use.
Tubulin polymerization-IN-55 is a potent inhibitor of Tubulin Polymerization. Tubulin polymerization-IN-55 has antiproliferative activity against A549, K562, HepG2, MDA-MB-231 and HFL-1 with IC50 s of 8, 3, 9, 24 and 62 nM, respectively[1].
| Catalog Number | I040580 |
| CAS Number | 2942396-29-2 |
| Synonyms | 1-(1-ethylindol-5-yl)-5,6,7-trimethoxy-2,3-dihydroquinolin-4-one |
| Molecular Formula | C22H24N2O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H24N2O4/c1-5-23-10-8-14-12-15(6-7-16(14)23)24-11-9-18(25)20-17(24)13-19(26-2)21(27-3)22(20)28-4/h6-8,10,12-13H,5,9,11H2,1-4H3 |
| InChIKey | DTEIZRBQUNGXFO-UHFFFAOYSA-N |
| SMILES | CCN1C=CC2=C1C=CC(=C2)N3CCC(=O)C4=C(C(=C(C=C43)OC)OC)OC |
| Reference | [1]. Tan Y, et al. Design, synthesis and biological evaluation of novel dihydroquinolin-4(1H)-one derivatives as novel tubulin polymerization inhibitors. Eur J Med Chem. 2023 Oct 15;262:115881. |
