For research use only. Not for therapeutic Use.
Tubulin polymerization-IN-56 (compound 8l), an indazole derivative, is a potent tubulin polymerization inhibitor through interacting with the colchicine site, resulting in cell cycle arrest and cellular apoptosis. polymerization-IN-56 reduces cell migration and leads to more potent inhibition of tumor growth in vivo[1].
| Catalog Number | I040579 |
| CAS Number | 2966790-98-5 |
| Synonyms | 6-(6-methylpyridin-3-yl)-1-(3,4,5-trimethoxyphenyl)indazole;hydrochloride |
| Molecular Formula | C22H22ClN3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H21N3O3.ClH/c1-14-5-6-16(12-23-14)15-7-8-17-13-24-25(19(17)9-15)18-10-20(26-2)22(28-4)21(11-18)27-3;/h5-13H,1-4H3;1H |
| InChIKey | WDNWWTXWTVQXBF-UHFFFAOYSA-N |
| SMILES | CC1=NC=C(C=C1)C2=CC3=C(C=C2)C=NN3C4=CC(=C(C(=C4)OC)OC)OC.Cl |
| Reference | [1]. Ying-Jie Cui, et al. The discovery of water-soluble indazole derivatives as potent microtubule polymerization inhibitors. Eur J Med Chem. 2023 Oct 18:262:115870. |
