For research use only. Not for therapeutic Use.
Tubulysin A（Cat No.:I002581）is a potent cytotoxic peptide derived from myxobacteria, known for its strong antitumor activity. It functions by binding to tubulin, disrupting microtubule dynamics, and inhibiting cell division, leading to apoptosis in rapidly dividing cancer cells. Tubulysin A is particularly valuable in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy, as it can deliver its cytotoxic effects directly to tumor cells while minimizing damage to healthy tissues. Its efficacy against various cancer types makes Tubulysin A a promising candidate for advanced oncological research and therapeutic applications.
| Catalog Number | I002581 |
| CAS Number | 205304-86-5 |
| Synonyms | (2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoic acid |
| Molecular Formula | C43H65N5O10S |
| Purity | ≥95% |
| IUPAC Name | (2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoic acid |
| InChI | InChI=1S/C43H65N5O10S/c1-10-27(6)38(46-40(53)34-13-11-12-18-47(34)9)42(54)48(24-57-37(51)19-25(2)3)35(26(4)5)22-36(58-29(8)49)41-45-33(23-59-41)39(52)44-31(20-28(7)43(55)56)21-30-14-16-32(50)17-15-30/h14-17,23,25-28,31,34-36,38,50H,10-13,18-22,24H2,1-9H3,(H,44,52)(H,46,53)(H,55,56)/t27-,28-,31+,34+,35+,36+,38-/m0/s1 |
| InChIKey | IBEDDHUHZBDXGB-OEJISELMSA-N |
| SMILES | CCC(C)C(C(=O)N(COC(=O)CC(C)C)C(CC(C1=NC(=CS1)C(=O)NC(CC2=CC=C(C=C2)O)CC(C)C(=O)O)OC(=O)C)C(C)C)NC(=O)C3CCCCN3C |
