Tucidinostat

For research use only. Not for therapeutic Use.

  • CAT Number: I009908
  • CAS Number: 1616493-44-7
  • PubChem Substance ID: 12136798
  • Molecular Formula: C22H19FN4O2
  • Molecular Weight: 390.41
  • Purity: ≥95%
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Tucidinostat(Cat No.:I009908), also known as Chidamide, is a selective histone deacetylase (HDAC) inhibitor that targets HDAC subtypes 1, 2, 3, and 10. By inhibiting HDAC activity, Tucidinostat induces histone acetylation, leading to the reactivation of tumor suppressor genes and promoting cancer cell apoptosis and cell cycle arrest. It is primarily used in the treatment of hematological malignancies, such as peripheral T-cell lymphoma (PTCL) and other cancers. Tucidinostat’s selective inhibition of specific HDACs minimizes off-target effects, making it a valuable agent in targeted cancer therapies and epigenetic research.


Catalog Number I009908
CAS Number 1616493-44-7
Synonyms

Tucidinostat; HBI-8000; HBI 8000; HBI8000 Chidamide; CS-055; CS 055; CS055;(E)-N-(2-amino-4-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide

Molecular Formula C22H19FN4O2
Purity ≥95%
Target Epigenetics
Solubility Soluble in DMSO
Storage Store at -20°C
IUPAC Name N-(2-amino-4-fluorophenyl)-4-[[[(E)-3-pyridin-3-ylprop-2-enoyl]amino]methyl]benzamide
InChI InChI=1S/C22H19FN4O2/c23-18-8-9-20(19(24)12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)/b10-5+
InChIKey SZMJVTADHFNAIS-BJMVGYQFSA-N
SMILES C1=CC(=CN=C1)C=CC(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=C(C=C3)F)N
Reference

</br>1: Gao S, Li X, Zang J, Xu W, Zhang Y. Preclinical and clinical studies of chidamide (CS055/HBI-8000), an orally available subtype-selective HDAC inhibitor for cancer therapy. Anticancer Agents Med Chem. 2016 Sep 1. [Epub ahead of print] PubMed PMID: 27592546.</br>2:Hasegawa H, Bissonnette RP, Gillings M, Sasaki D, Taniguchi H, Kitanosono H, Tsuruda K, Kosai K, Uno N, Morinaga Y, Imaizumi Y, Miyazaki Y, Yanagihara K. Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3. Cancer Sci. 2016 Aug;107(8):1124-33. doi: 10.1111/cas.12971. Epub 2016 Jun 22. PubMed PMID: 27193821; PubMed Central PMCID: PMC4982578.</br>3:Dong M, Ning ZQ, Xing PY, Xu JL, Cao HX, Dou GF, Meng ZY, Shi YK, Lu XP, Feng FY. Phase I study of chidamide (CS055/HBI-8000), a new histone deacetylase inhibitor, in patients with advanced solid tumors and lymphomas. Cancer Chemother Pharmacol. 2012 Jun;69(6):1413-22. doi: 10.1007/s00280-012-1847-5. Epub 2012 Feb 24. PubMed PMID: 22362161.

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