Tulathromycin A

• CAT Number: I002663
• CAS Number: 217500-96-4
• Molecular Formula: C41H79N3O12
• Molecular Weight: 806.10
• Purity: ≥95%
• Synonyms: 11-((4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-((5-hydroxy-4-methoxy-4,6-dimethyl-5-((propylamino)methyl)tetrahydro-2H-pyran-2-yl)oxy)-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
• Target: Antibiotic
• Solubility: DMSO: ≥ 45 mg/mL
• Storage: Store at -20°C
• IC50: 1 microg/ml (MIC90 for Pasteurella multocida) [2]
• IUPAC Name: (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-(propylaminomethyl)oxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one
• InChI: InChI=1S/C41H79N3O12/c1-15-17-42-22-41(50)28(8)53-31(20-39(41,10)51-14)55-33-25(5)35(56-37-32(45)29(44(12)13)18-24(4)52-37)38(9,48)19-23(3)21-43-27(7)34(46)40(11,49)30(16-2)54-36(47)26(33)6/h23-35,37,42-43,45-46,48-50H,15-22H2,1-14H3/t23-,24-,25+,26-,27-,28+,29+,30-,31+,32-,33+,34-,35-,37+,38-,39-,40-,41+/m1/s1
• InChIKey: GUARTUJKFNAVIK-QPTWMBCESA-N
• SMILES: CCCNC[C@@]1([C@@H](O[C@H](C[C@@]1(C)OC)O[C@H]2[C@@H]([C@H]([C@](C[C@H](CN[C@@H]([C@H]([C@]([C@H](OC(=O)[C@@H]2C)CC)(C)O)O)C)C)(C)O)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)C)C)O

Tulathromycin A（Cat No.:I002663）is a macrolide antibiotic widely used in veterinary medicine for treating respiratory infections in cattle, swine, and other livestock. It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, making it effective against Gram-positive and Gram-negative bacteria, including Pasteurella multocida and Mycoplasma species. Tulathromycin A’s long-acting formulation and excellent tissue penetration provide prolonged therapeutic effects, reducing the need for frequent dosing. It is a valuable tool for research on macrolide mechanisms, resistance development, and optimizing antibiotic use in veterinary medicine to ensure animal health and productivity.

Reference

[1]. Godinho KS, et al. Efficacy of tulathromycin in the treatment of bovine respiratory disease associated with induced Mycoplasma bovis infections in young dairy calves. Vet Ther. 2005 Summer;6(2):96-112.
[2]. Godinho KS, et al. Minimum inhibitory concentrations of tulathromycin against respiratory bacterial pathogens isolated from clinical cases in European cattle and swine and variability arising from changes in in vitro methodology. Vet Ther. 2005 Summer;6(2):113-21.
[3]. Rooney KA, et al. Efficacy of tulathromycin compared with tilmicosin and florfenicol for the control of respiratory disease in cattle at high risk of developing bovine respiratory disease. Vet Ther. 2005 Summer;6(2):154-66.
[4]. Kilgore WR, et al. Therapeutic efficacy of tulathromycin, a novel triamilide antimicrobial, against bovine respiratory disease in feeder calves. Vet Ther. 2005 Summer;6(2):143-53.