Tulathromycin B

• CAT Number: R061092
• CAS Number: 280755-12-6
• Molecular Formula: C41H79N3O12
• Molecular Weight: 806.08
• Purity: ≥95%
• Synonyms: (2S,3S,6R,8R,9R,10S,11S,12R)-2-[(2R,3R)-2,3-dihydroxypentan-2-yl]-9-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-8-hydroxy-11-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-(propylaminomethyl)oxan-2-yl]oxy-3,6,8,10,12-pentamethyl-1-oxa-4-azacyclotridecan-13-one
• IUPAC Name: (2R,3R,6R,8R,9R,10S,11S,12R)-2-[(2R,3R)-2,3-dihydroxypentan-2-yl]-9-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-8-hydroxy-11-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-5-(propylaminomethyl)oxan-2-yl]oxy-3,6,8,10,12-pentamethyl-1-oxa-4-azacyclotridecan-13-one
• InChI: InChI=1S/C41H79N3O12/c1-15-17-42-22-41(50)28(8)53-31(20-39(41,10)51-14)54-33-25(5)34(56-37-32(46)29(44(12)13)18-24(4)52-37)38(9,48)19-23(3)21-43-27(7)35(55-36(47)26(33)6)40(11,49)30(45)16-2/h23-35,37,42-43,45-46,48-50H,15-22H2,1-14H3/t23-,24-,25+,26-,27+,28+,29+,30-,31+,32-,33+,34-,35+,37+,38-,39-,40-,41+/m1/s1
• InChIKey: JEBMHQVCOAWRCT-CAHYNIAPSA-N
• SMILES: CCCNCC1(C(OC(CC1(C)OC)OC2C(C(C(CC(CNC(C(OC(=O)C2C)C(C)(C(CC)O)O)C)C)(C)O)OC3C(C(CC(O3)C)N(C)C)O)C)C)O

Tulathromycin B(CAT: R061092) is a semi-synthetic macrolide antibiotic belonging to the triamilide subclass, primarily used in veterinary medicine. It exhibits broad-spectrum activity against Gram-positive and Gram-negative bacteria, including respiratory pathogens such as Mannheimia haemolytica, Pasteurella multocida, and Actinobacillus pleuropneumoniae. Tulathromycin B works by binding to the 50S ribosomal subunit, inhibiting bacterial protein synthesis. Its long half-life and strong tissue penetration make it particularly effective for treating respiratory infections in livestock. While primarily applied in veterinary settings, it is also used in microbiological research.