For research use only. Not for therapeutic Use.
Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1].
Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM)[1].
Tumulosic acid decreases in LL-37 production in human keratinocytes[1].
Tumulosic acid shows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)[1].
| Catalog Number | I044791 |
| CAS Number | 508-24-7 |
| Synonyms | (2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3,16-dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid |
| Molecular Formula | C31H50O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C31H50O4/c1-18(2)19(3)9-10-20(27(34)35)26-23(32)17-31(8)22-11-12-24-28(4,5)25(33)14-15-29(24,6)21(22)13-16-30(26,31)7/h18,20,23-26,32-33H,3,9-17H2,1-2,4-8H3,(H,34,35)/t20-,23-,24+,25+,26+,29-,30-,31+/m1/s1 |
| InChIKey | XADJANKGURNTIA-YEXRKOARSA-N |
| SMILES | CC(C)C(=C)CCC(C1C(CC2(C1(CCC3=C2CCC4C3(CCC(C4(C)C)O)C)C)C)O)C(=O)O |
| Reference | [1]. Matsubara Y, et al. Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources. Molecules. 2017;22(11):1829. Published 2017 Oct 27. |
