Tunicamycin V

• CAT Number: I037615
• CAS Number: 66054-36-2
• Molecular Formula: C38H62N4O16
• Molecular Weight: 830.93
• Purity: 98%
• Synonyms: Tunicamycin A; Tunicamycin B1
• Target: Bacterial
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (E)-N-[(2S,3R,4R,5R,6R)-2-[(2R,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[(2R)-2-[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl]-4,5-dihydroxyoxan-3-yl]-13-methyltetradec-2-enamide
• InChI: InChI=1S/C38H62N4O16/c1-19(2)13-11-9-7-5-4-6-8-10-12-14-24(46)40-27-31(51)28(48)22(55-37(27)58-36-26(39-20(3)44)30(50)29(49)23(18-43)56-36)17-21(45)34-32(52)33(53)35(57-34)42-16-15-25(47)41-38(42)54/h12,14-16,19,21-23,26-37,43,45,48-53H,4-11,13,17-18H2,1-3H3,(H,39,44)(H,40,46)(H,41,47,54)/b14-12+/t21-,22-,23-,26-,27-,28+,29-,30-,31-,32+,33-,34-,35-,36-,37+/m1/s1
• InChIKey: MEYZYGMYMLNUHJ-DIRMKAHISA-N
• SMILES: CC(C)CCCCCCCCCC=CC(=O)NC1C(C(C(OC1OC2C(C(C(C(O2)CO)O)O)NC(=O)C)CC(C3C(C(C(O3)N4C=CC(=O)NC4=O)O)O)O)O)O

Tunicamycin V（Cat No.:I037615）, also known as Tunicamycin A, is a nucleoside natural product with potent inhibitory activity against bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY). It displays an IC50 value of 0.35 μM against MraY, making it an effective inhibitor of this bacterial enzyme. Tunicamycin V also exhibits antibacterial activity, which is attributed to its ability to disrupt the biosynthesis of the bacterial cell wall. These properties make Tunicamycin V a valuable compound for studying bacterial cell wall synthesis and as a potential therapeutic agent against bacterial infections.