TVB-3166

• CAT Number: I017970
• CAS Number: 1533438-83-3
• Molecular Formula: C₂₄H₂₄N₄O
• Molecular Weight: 384.47
• Purity: ≥95%
• Target: Apoptosis
• IUPAC Name: 4-[1-[5-(4,5-dimethyl-1H-pyrazol-3-yl)-2,4-dimethylbenzoyl]azetidin-3-yl]benzonitrile
• InChI: InChI=1S/C24H24N4O/c1-14-9-15(2)22(10-21(14)23-16(3)17(4)26-27-23)24(29)28-12-20(13-28)19-7-5-18(11-25)6-8-19/h5-10,20H,12-13H2,1-4H3,(H,26,27)
• InChIKey: ICDQFUFDAFKCAX-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C=C1C2=NNC(=C2C)C)C(=O)N3CC(C3)C4=CC=C(C=C4)C#N)C

TVB-3166（Cat No.:I017970）is a potent, selective inhibitor of fatty acid synthase (FASN), a critical enzyme in lipid biosynthesis. By targeting FASN, TVB-3166 disrupts lipid metabolism, making it a valuable compound for cancer research, particularly in studying cancer cell growth and survival. This high-purity inhibitor is essential for exploring metabolic pathways in oncology, where FASN inhibition has shown potential in limiting tumor proliferation. With its stable formulation and precise action, TVB-3166 supports in-depth investigations into metabolic therapies, advancing innovative approaches in cancer treatment and research.

Reference

[1]. Ventura R, et al. Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression. EBioMedicine. 2015 Jul 2;2(8):808-24.