Tyrosinase-IN-2

• CAT Number: I043716
• CAS Number: 180864-33-9
• Molecular Formula: C8H8N4O2S
• Molecular Weight: 224.24
• Purity: ≥95%
• Synonyms: [(E)-(4-nitrophenyl)methylideneamino]thiourea
• InChI: InChI=1S/C8H8N4O2S/c9-8(15)11-10-5-6-1-3-7(4-2-6)12(13)14/h1-5H,(H3,9,11,15)/b10-5+
• InChIKey: HSDCBIHJEGDMDO-BJMVGYQFSA-N
• SMILES: C1=CC(=CC=C1C=NNC(=S)N)[N+](=O)[O-]

Tyrosinase-IN-2 (compound 67) is a potent inhibitor of tyrosinase. Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting catalytic step in the melanin biosynthesis and enzymatic browning. Tyrosinase-IN-2 has the potential for the research of skin whitening agents and food preservatives[1].

Reference

[1]. Li J, et al. Recent advances in the design and discovery of synthetic tyrosinase inhibitors. Eur J Med Chem. 2021;224:113744.
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