Tyrosine kinase-IN-7

• CAT Number: I040526
• CAS Number: 345615-74-9
• Molecular Formula: C16H15N3OS
• Molecular Weight: 297.37
• Purity: ≥95%
• Synonyms: 4-(5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-ylamino)phenol
• InChI: InChI=1S/C16H15N3OS/c20-11-7-5-10(6-8-11)19-15-14-12-3-1-2-4-13(12)21-16(14)18-9-17-15/h5-9,20H,1-4H2,(H,17,18,19)
• InChIKey: BTIBWAOCLJARHL-UHFFFAOYSA-N
• SMILES: C1CCC2=C(C1)C3=C(N=CN=C3S2)NC4=CC=C(C=C4)O

Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC50s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively[1].

Reference

[1]. Elmetwally SA, et al. Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers. Bioorg Chem. 2019 Jul;88:102944.
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