For research use only. Not for therapeutic Use.
Tyrothricin(Cat No.:M050812) is a complex mixture of cyclic and linear polypeptide antibiotics, primarily composed of tyrocidine and gramicidin, isolated from Bacillus brevis. It exhibits potent antibacterial activity, particularly against Gram-positive bacteria, by disrupting bacterial cell membranes and causing cell lysis. Tyrothricin is primarily used in topical applications to treat infections of the skin and mucous membranes, such as wounds, ulcers, and sore throats. Its mechanism of action involves increasing membrane permeability, which leads to the leakage of essential cellular components. It is valuable in microbiology and pharmaceutical research for studying antibiotic mechanisms and developing new antimicrobial therapies.
| Catalog Number | M050812 |
| CAS Number | 1404-88-2 |
| Molecular Formula | C65H85N11O13 |
| Purity | ≥95% |
| Target | Bacterial |
| Storage | -20°C |
| IUPAC Name | 3-[(3R,6S,9S,12S,15S,17S,20S,22R,25S,28S)-20-(2-amino-2-oxoethyl)-9-(3-aminopropyl)-3,22,25-tribenzyl-15-[(4-hydroxyphenyl)methyl]-6-(2-methylpropyl)-2,5,8,11,14,18,21,24,27-nonaoxo-12-propan-2-yl-1,4,7,10,13,16,19,23,26-nonazabicyclo[26.3.0]hentriacontan-17-yl]propanoic acid |
| InChI | InChI=1S/C65H85N11O13/c1-38(2)32-49-60(84)74-52(36-42-20-12-7-13-21-42)65(89)76-31-15-23-53(76)63(87)73-51(34-41-18-10-6-11-19-41)61(85)70-47(33-40-16-8-5-9-17-40)57(81)48(37-54(67)78)71-59(83)46(28-29-55(79)80)68-50(35-43-24-26-44(77)27-25-43)62(86)75-56(39(3)4)64(88)69-45(22-14-30-66)58(82)72-49/h5-13,16-21,24-27,38-39,45-53,56,68,77H,14-15,22-23,28-37,66H2,1-4H3,(H2,67,78)(H,69,88)(H,70,85)(H,71,83)(H,72,82)(H,73,87)(H,74,84)(H,75,86)(H,79,80)/t45-,46-,47+,48-,49-,50-,51-,52+,53-,56-/m0/s1 |
| InChIKey | NLJVXZFCYKWXLH-DXTIXLATSA-N |
| SMILES | CC(C)CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)NC(C(=O)C(NC(=O)C(NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN)C(C)C)CC3=CC=C(C=C3)O)CCC(=O)O)CC(=O)N)CC4=CC=CC=C4)CC5=CC=CC=C5)CC6=CC=CC=C6 |
