Tyrphostin A1

• CAT Number: I002958
• CAS Number: 2826-26-8
• Molecular Formula: C11H8N2O
• Molecular Weight: 184.19
• Purity: ≥95%
• Target: Interleukin Related
• Solubility: ethanol：25 mg/ml ；DMSO：25 mg/ml； chloroform：50 mg/ml ；
• Storage: Store at -20°C
• IUPAC Name: 2-[(4-methoxyphenyl)methylidene]propanedinitrile
• InChI: InChI=1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
• InChIKey: UOHFCPXBKJPCAD-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)C=C(C#N)C#N

Tyrphostin A1（Cat No.:I002958）is a synthetic, small molecule tyrosine kinase inhibitor that selectively targets the epidermal growth factor receptor (EGFR) and other receptor tyrosine kinases. It functions by blocking the autophosphorylation of these receptors, which are critical in regulating cell growth, differentiation, and survival. By inhibiting EGFR signaling, Tyrphostin A1 has shown potential in inhibiting tumor cell proliferation, making it a candidate for cancer therapy. It is often used in laboratory research to study the role of tyrosine kinases in cancer and other diseases, although it has limited clinical use due to its specificity and toxicity.

Reference

[1]. Du C, et al. Inhibition of CD40 signaling pathway by tyrphostin A1 reduces secretion of IL-12 in macrophage, Th1 cell development and experimental allergic encephalomyelitis in SJL/J mice. J Neuroimmunol. 2001 Mar 1;114(1-2):69-79.
[2]. Ogura T, et al. Activation of background membrane conductance by the tyrosine kinase inhibitor tyrphostin A23 and its inactive analog tyrphostin A1 in guinea pig ventricular myocytes. Jpn J Pharmacol. 2001 Nov;87(3):235-9.