For research use only. Not for therapeutic Use.
Tyrphostin A9（Cat No.:I000285）is a selective inhibitor of tyrosine kinases, particularly targeting platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR). By blocking these receptors, Tyrphostin A9 interferes with the signaling pathways involved in cell growth, differentiation, and angiogenesis. This makes it a valuable tool in cancer research, as well as studies focused on abnormal cell proliferation and vascular diseases. Its ability to inhibit tyrosine kinase activity offers insights into developing therapeutic strategies for cancer, atherosclerosis, and other disorders linked to excessive cellular growth and angiogenesis.
| Catalog Number | I000285 |
| CAS Number | 10537-47-0 |
| Synonyms | 2-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile |
| Molecular Formula | C18H22N2O |
| Purity | ≥95% |
| Target | VEGFR |
| Solubility | 10 mM in DMSO |
| Storage | 3 years -20C powder |
| IUPAC Name | 2-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile |
| InChI | InChI=1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3 |
| InChIKey | MZOPWQKISXCCTP-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N |
| Reference | </br>1:A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation. Park SJ, Park YJ, Shin JH, Kim ES, Hwang JJ, Jin DH, Kim JC, Cho DH.Biochem Biophys Res Commun. 2011 May 13;408(3):465-70. doi: 10.1016/j.bbrc.2011.04.053. Epub 2011 Apr 19. PMID: 21527248 </br>2:Abnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts. Lakkakorpi PT, Nakamura I, Young M, Lipfert L, Rodan GA, Duong LT.J Cell Sci. 2001 Jan;114(Pt 1):149-160. PMID: 11112699 Free Article</br>3:Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells. Thyberg J.Eur J Cell Biol. 1998 May;76(1):33-42. PMID: 9650781 </br>4:Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channel in Jurkat T cells. Marhaba R, Mary F, Pelassy C, Stanescu AT, Aussel C, Breittmayer JP.J Immunol. 1996 Aug 15;157(4):1468-73. PMID: 8759727 |
