For research use only. Not for therapeutic Use.
AG 126 selectively inhibits the phosphorylation. It also acts as a cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.
| Catalog Number | M029555 |
| CAS Number | 118409-62-4 |
| Synonyms | 2-[(3-hydroxy-4-nitrophenyl)methylene]-propanedinitrile |
| Molecular Formula | C10H5N3O3 |
| Purity | ≥95% |
| Target | Stem Cell/Wnt |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| InChI | InChI=1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H |
| InChIKey | DUQADSPERJRQBW-UHFFFAOYSA-N |
| SMILES | OC1=C([N+]([O-])=O)C=CC(/C=C(C#N)C#N)=C1 |
| Reference | </br>1:Tyrphostin AG 126 reduces intestinal ischemia-reperfusion injury in the rat. Marzocco S, Mazzon E, Pinto A, Autore G, Cuzzocrea S.Naunyn Schmiedebergs Arch Pharmacol. 2006 Feb;372(5):362-73. Epub 2006 Feb 17. PMID: 16485131 </br>2:Tyrphostin AG 126 inhibits development of postoperative ileus induced by surgical manipulation of murine colon. Moore BA, Türler A, Pezzone MA, Dyer K, Grandis J, Bauer AJ.Am J Physiol Gastrointest Liver Physiol. 2004 Feb;286(2):G214-24. Epub 2003 Sep 25. PMID: 14512290 Free Article</br>3:The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat. Dugo L, Chatterjee PK, Mazzon E, McDonald MC, Paola RD, Fulia F, Caputi AP, Thiemermann C, Cuzzocrea S.Intensive Care Med. 2002 Jun;28(6):775-88. Epub 2002 Apr 30. PMID: 12107686 </br>4:The tyrosine kinase inhibitor tyrphostin AG 126 reduced the development of colitis in the rat. Cuzzocrea S, McDonald MC, Mazzon E, Mota-Filipe H, Lepore V, Ciccolo A, Terranova ML, Britti D, Caputi AP, Thiemermann C.Lab Invest. 2000 Sep;80(9):1439-53. PMID: 11005212 |
