For research use only. Not for therapeutic Use.
Tyrphostin AG 490 (Cat.No:I001280) is a selective inhibitor of Janus kinase (JAK) and epidermal growth factor receptor (EGFR) tyrosine kinases. It has been extensively studied for its potential in inhibiting cell proliferation and signaling pathways associated with cancer and inflammatory diseases. Tyrphostin AG 490 holds promise as a targeted therapy in preclinical studies.
| CAS Number | 133550-30-8 |
| Synonyms | (E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide |
| Molecular Formula | C₁₇H₁₄N₂O₃ |
| Purity | ≥95% |
| Target | Protein Tyrosine Kinase/RTK |
| Solubility | DMSO ≥57mg/mL Water <1.2mg/mL Ethanol ≥8mg/mL |
| Storage | store at -20℃ |
| IC50 | 0.1 uM (EGFR)[1]; 10 uM (JAK2) |
| InChI | InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+ |
| InChIKey | TUCIOBMMDDOEMM-RIYZIHGNSA-N |
| SMILES | C1=CC=C(C=C1)CNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
